Non-alcoholic fatty liver disease and its associated risk factors in Brazilian postmenopausal women

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dc.contributor.authorSouza Bruno, A. de [UNESP]
dc.contributor.authorRodrigues, M. H. [UNESP]
dc.contributor.authorAlvares, M. C. B.
dc.contributor.authorNahas-Neto, J. [UNESP]
dc.contributor.authorNahás, Eliana Aguiar Petri [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Ouro Preto
dc.contributor.institutionUltrasound Serv Santa Casa Hosp Belo Horizonte
dc.date.accessioned2015-03-18T15:56:19Z
dc.date.available2015-03-18T15:56:19Z
dc.date.issued2014-08-01
dc.description.abstractObjective To evaluate the prevalence and risk factors of non-alcoholic fatty liver disease (NAFLD) in postmenopausal women.Methods A cross-sectional study was carried involving 188 women (age >= 45 years and amenorrhea >= 12 months) attending the outpatient unit in south-eastern Brazil. Exclusion criteria were liver disease (hepatitis B and C, cholestatic disease, liver insufficiency), use of drugs that affect liver metabolism; alcoholics; AIDS or cancer history; and morbid obesity. NAFLD was diagnosed by abdominal ultrasound. Clinical, anthropometric (body mass index, waist circumference) and biochemical variables were measured.Results Of the 188 women, 73 (38.8%) had NAFLD. Blood pressure, waist circumference, body mass index, LDL cholesterol, triglycerides and glucose were significantly higher in NAFLD patients when compared with women without NAFLD (control group) (p < 0.05). HOMA-IR values indicated insulin resistance only in the NAFLD group (6.1 +/- 4.6 vs. 2.4 +/- 1.4 in control group, p < 0.05). Metabolic syndrome was detected in 93.1% of the women affected by NAFLD, and 46.1% of the control group (p < 0.05). In multivariate analysis, adjusted for age and weight, the variables considered at risk for the development of NAFLD, were: high waist circumference (odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01-1.13), insulin resistance (OR 3.81, 95% CI 2.01-7.13), and presence of metabolic syndrome (OR 8.68, 95% CI 3.3-24.1).Conclusion NAFLD showed a high prevalence among postmenopausal women. The presence of metabolic syndrome, abdominal obesity and IR were indicators of risk for the development of NAFLD.en
dc.description.affiliationSao Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Ouro Preto, Dept Gynecol & Obstet, Ouro Preto, MG, Brazil
dc.description.affiliationUltrasound Serv Santa Casa Hosp Belo Horizonte, Belo Horizonte, MG, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, Sao Paulo, Brazil
dc.description.sponsorshipSanta Casa Hospital of Belo Horizonte, Minas Gerais, Brazil
dc.format.extent465-471
dc.identifierhttp://dx.doi.org/10.3109/13697137.2014.881353
dc.identifier.citationClimacteric. London: Informa Healthcare, v. 17, n. 4, p. 465-471, 2014.
dc.identifier.doi10.3109/13697137.2014.881353
dc.identifier.issn1369-7137
dc.identifier.lattes4155170574788417
dc.identifier.urihttp://hdl.handle.net/11449/117486
dc.identifier.wosWOS:000339698900021
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofClimacteric
dc.relation.ispartofjcr2.807
dc.relation.ispartofsjr0,772
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMENOPAUSEen
dc.subjectNON-ALCOHOLIC FATTY LIVER DISEASEen
dc.subjectINSULIN RESISTANCEen
dc.subjectMETABOLIC SYNDROMEen
dc.titleNon-alcoholic fatty liver disease and its associated risk factors in Brazilian postmenopausal womenen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderInforma Healthcare
unesp.author.lattes4155170574788417
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB