Paracoccidioidomycosis associated with immunosuppression, AIDS, and Cancer

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dc.contributor.authorMarques, Silvio Alencar [UNESP]
dc.contributor.authorShikanai-Yasuda, Maria Aparecida
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T17:06:30Z
dc.date.available2019-10-06T17:06:30Z
dc.date.issued2018-01-01
dc.description.abstractThis chapter presents clinical, diagnostic, and therapeutic aspects of the mycosis when associated to immunosuppressive conditions. Antifungal therapy proved unsuccessful in patients with severe forms of paracoccidioidomycosis indicating that in addition to treatment of the underlying disease, these patients should also receive a long course of antifungal therapy. Most of the neoplasias associated to paracoccidioidomycosis were carcinomas. The association paracoccidioidomycosis and cancer is an important one which should be approached from a multidisciplinary point of view in order to further contribute to the knowledge of the host-parasite relationship in paracoccidioidomycosis. An interpretation of the low antibody titers detect in AIDS-associated paracoccidioidomycosis may be given by the immunopathogenesis of HIV infection. In AIDS patients, although B cells proliferate and show polyclonal activation, they have a defect in their ability to secrete antigen-specific immunoglobulins. AIDS-associated paracoccidioidomycosis should be considered a real and serious complications which presents new challenges to clinicians and investigators living in endemic countries.en
dc.description.affiliationBotucatu Medical School University of the State of São Paulo (UNESP)
dc.description.affiliationDepartment of Infectious Diseases São Paulo University School of Medicine (USP)
dc.description.affiliationUnespBotucatu Medical School University of the State of São Paulo (UNESP)
dc.format.extent393-405
dc.identifierhttp://dx.doi.org/10.1201/9781351075329
dc.identifier.citationParacoccidioidomycosis, p. 393-405.
dc.identifier.doi10.1201/9781351075329
dc.identifier.scopus2-s2.0-85063505320
dc.identifier.urihttp://hdl.handle.net/11449/190230
dc.language.isoeng
dc.relation.ispartofParacoccidioidomycosis
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.titleParacoccidioidomycosis associated with immunosuppression, AIDS, and Canceren
dc.typeCapítulo de livro
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDermatologia e Radioterapia - FMBpt

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Botucatu - FMB - Faculdade de Medicina