Clinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosis

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dc.contributor.authorKather, Jorge
dc.contributor.authorCastillo Salgado, Miguel Angel [UNESP]
dc.contributor.authorLodi Salgado, Ulisses Fernando
dc.contributor.authorCortelli, Jose Roberto
dc.contributor.authorPallos, Debora
dc.contributor.institutionUniv Taubate
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:41Z
dc.date.available2014-05-20T14:04:41Z
dc.date.issued2008-03-01
dc.description.abstractObjective. To examine the histomorphologic and histomorphometric features of tissue from 3 unrelated families with hereditary gingival fibromatosis (HGF).Study design. Twelve affected individuals from 3 HGF families and 3 control subjects were evaluated. Gingival samples were fixed in formalin and embedded in paraffin for hematoxylin and eosin stain to count the number of fibroblast and inflammatory cells. Sirius red staining was performed to quantitate the amount of collagen present.Results. Histomorphologic analysis of HGF showed extension of epithelial rete ridges into the underlying lamina propria and the presence of collagen bundles in the connective tissue. Analysis of the mean area fraction of collagen showed that there were significant increases in the collagen fraction for all HGF types compared with control subjects (P < .05). There were significant increases in the number of fibroblasts for HGFa and HGFb compared with control subjects (P < .05). The number of fibroblasts for HGFc were similar to that for control subjects.Conclusions. The collagen fraction was significantly greater in all HGF types compared with controls. The number of fibroblasts was significantly increased in 2 of the 3 HGF types compared with controls. These data indicate that different mechanisms may be responsible for tissue enlargement in different forms of HGF.en
dc.description.affiliationUniv Taubate, Dept Periodontol, Taubate, Brazil
dc.description.affiliationSão Paulo State Univ, Sch Dent, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent, São Paulo, Brazil
dc.format.extent348-352
dc.identifierhttp://dx.doi.org/10.1016/j.tripleo.2007.06.006
dc.identifier.citationOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology. New York: Mosby-elsevier, v. 105, n. 3, p. 348-352, 2008.
dc.identifier.doi10.1016/j.tripleo.2007.06.006
dc.identifier.issn1079-2104
dc.identifier.lattes8235700830441386
dc.identifier.urihttp://hdl.handle.net/11449/22697
dc.identifier.wosWOS:000253603600015
dc.language.isoeng
dc.publisherMosby-elsevier
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleClinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderMosby-elsevier
unesp.author.lattes8235700830441386
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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