Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole

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dc.contributor.authorPaiva, SAR
dc.contributor.authorSepe, T. E.
dc.contributor.authorBooth, S. L.
dc.contributor.authorCamilo, M. E.
dc.contributor.authorO'Brien, M. E.
dc.contributor.authorDavidson, K. W.
dc.contributor.authorSadowski, J. A.
dc.contributor.authorRussell, R. M.
dc.contributor.institutionTufts Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:20:36Z
dc.date.available2014-05-20T15:20:36Z
dc.date.issued1998-09-01
dc.description.abstractSubjects taking a hydrogen pump blocking agent (omeprazole) develop bacterial overgrowth of the small intestine. We tested the hypothesis that this bacterial overgrowth produces menaquinones, which would meet the Vitamin requirement in situations of vitamin K deficiency. In a crossover-type design, 13 healthy Volunteers eating a phylloquinone-restricted diet for 35 d were randomly assigned to take omeprazole during the first period of study or starting on day 15 until the end of the study. Coagulation times, serum osteocalcin [total osteocalcin and undercarboxylated osteocalcin (ucOC)], plasma phylloquinone, urinary gamma-carboxyglutamic acid, and plasma undercarboxylated prothrombin (PIVKA-II) were measured. Plasma phylloquinone concentrations declined 82% with dietary phylloquinone restriction (P < 0.05) and were not significantly different in the period when the diet was combined with omeprazole treatment (P > 0.05), the mean value for PIVKA-II during the phylloquinone-restricted diet significantly increased 5.7-fold from baseline (P < 0.05); however, the combination of omeprazole treatment and the phylloquinone-restricted diet significantly reduced PIVKA-II values by 21% (P < 0.05) compared with the diet period alone. There were no alterations in total or percentage ucOC concentrations during the phylloquinone-restricted diet or during the period of diet plus omeprazole treatment. Our data support the hypothesis that bacterial overgrowth results in the synthesis and absorption of menaquinones. These menaquinones contribute to vitamin K nutriture during dietary phylloquinone restriction, but not enough to restore normal vitamin K status.en
dc.description.affiliationTufts Univ, Human Nutr Res Ctr Aging, Jean Mayer US Dept Agr, Boston, MA 02111 USA
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, São Paulo, Brazil
dc.format.extent699-704
dc.identifierhttp://ajcn.nutrition.org/content/68/3/699
dc.identifier.citationAmerican Journal of Clinical Nutrition. Bethesda: Amer Soc Clinical Nutrition, v. 68, n. 3, p. 699-704, 1998.
dc.identifier.issn0002-9165
dc.identifier.urihttp://hdl.handle.net/11449/31871
dc.identifier.wosWOS:000075646100029
dc.language.isoeng
dc.publisherAmer Soc Clinical Nutrition
dc.relation.ispartofAmerican Journal of Clinical Nutrition
dc.relation.ispartofjcr6.549
dc.relation.ispartofsjr3,438
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectphylloquinonept
dc.subjectmenaquinonept
dc.subjectvitamin K statuspt
dc.subjectosteocalcinpt
dc.subjectprothrombinpt
dc.subjectPIVKA-IIpt
dc.subjectgamma-carboxyglutamic acidpt
dc.subjecturinary Glapt
dc.subjectbacterial overgrowthpt
dc.subjectomeprazolept
dc.titleInteraction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazoleen
dc.typeArtigo
dcterms.licensehttp://www.nutrition.org/publications/guidelines-and-policies/permissions/
dcterms.rightsHolderAmer Soc Clinical Nutrition
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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