Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study

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dc.contributor.authorAraujo-Souza, Patricia S. de
dc.contributor.authorRamanakumar, Agnihotram V.
dc.contributor.authorCandeias, Joao M. G. [UNESP]
dc.contributor.authorThomann, Patricia
dc.contributor.authorTrevisan, Andrea
dc.contributor.authorFranco, Eduardo L.
dc.contributor.authorVilla, Luisa L.
dc.contributor.institutionLudwig Inst Canc Res
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionBrazilian Natl Canc Inst
dc.contributor.institutionMcGill Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Gynaecol Canc Res
dc.contributor.institutionUniv Montreal
dc.contributor.institutionICESP
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSanta Casa Sao Paulo
dc.date.accessioned2015-03-18T15:55:51Z
dc.date.available2015-03-18T15:55:51Z
dc.date.issued2014-11-18
dc.description.abstractBackground: Immunity plays an important role in controlling human papillomavirus (HPV) infection and associated lesions. Unlike infections caused by other viruses, natural HPV infection does not always result in a protective antibody response. Therefore, HPV antibodies are also considered markers of cumulative exposure. The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia.Methods: HPV16 serology was assessed by ELISA for L1 and L2 capsid antigens, while HPV typing and viral load measurements were performed by PCR-based methods. The associations were analyzed by unconditional logistic regression.Results: Of 2049 subjects, 425 (20.7%) were strongly seropositive for HPV16. In multivariate analysis, seroreactivity was positively correlated with age, lifetime number of sexual partners, frequency of sex, and HPV16 viral load, and negatively associated with duration of smoking.Conclusions: HPV16 seroreactivity is determined by factors that reflect viral exposure.en
dc.description.affiliationLudwig Inst Canc Res, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Fluminense, Dept Immunobiol, Niteroi, RJ, Brazil
dc.description.affiliationBrazilian Natl Canc Inst, Program Cellular Biol, Rio De Janeiro, Brazil
dc.description.affiliationMcGill Univ, Dept Oncol, Montreal, PQ, Canada
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationInst Gynaecol Canc Res, Sao Paulo, Brazil
dc.description.affiliationUniv Montreal, CHUM, Div Gynecol Oncol, Montreal, PQ, Canada
dc.description.affiliationMcGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada
dc.description.affiliationICESP, Sao Paulo Canc Inst, Mol Biol Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Radiol & Oncol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Sao Paulo, Brazil
dc.description.affiliationSanta Casa Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.sponsorshipLudwig Institute for Cancer Research
dc.description.sponsorshipU.S. National Cancer Institute
dc.description.sponsorshipCanadian Institutes of Health Research
dc.description.sponsorshipIdU.S. National Cancer InstituteCA70269
dc.description.sponsorshipIdCanadian Institutes of Health Research49396
dc.description.sponsorshipIdCanadian Institutes of Health Research83320
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1186/s12879-014-0578-0
dc.identifier.citationBmc Infectious Diseases. London: Biomed Central Ltd, v. 14, 9 p., 2014.
dc.identifier.doi10.1186/s12879-014-0578-0
dc.identifier.fileWOS000345710200001.pdf
dc.identifier.issn1471-2334
dc.identifier.orcid0000-0003-1515-702X
dc.identifier.urihttp://hdl.handle.net/11449/117332
dc.identifier.wosWOS:000345710200001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Infectious Diseases
dc.relation.ispartofjcr2.620
dc.relation.ispartofsjr1,576
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectSerologyen
dc.subjectHPVen
dc.subjectNatural antibodiesen
dc.subjectHPV16 seropositivityen
dc.titleDeterminants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort studyen
dc.typeArtigo
dcterms.rightsHolderBiomed Central Ltd
unesp.author.orcid0000-0003-1515-702X[3]
unesp.author.orcid0000-0002-4409-8084[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB