Bone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetes

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dc.contributor.authorVieira, Evanice Menezes Marçal [UNESP]
dc.contributor.authorUeno, Camila Satie Ferreira [UNESP]
dc.contributor.authorValva, Vivian Neves [UNESP]
dc.contributor.authorGoulart, Maria das Graças Vilela [UNESP]
dc.contributor.authorNogueira, Terezinha de Oliveira [UNESP]
dc.contributor.authorGomes, Mônica Fernandes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:38Z
dc.date.available2014-05-27T11:23:38Z
dc.date.issued2008-08-04
dc.description.abstractThis research evaluated the bone repair process in surgical defects created on the parietal bones of diabetic rabbits using the guided bone regeneration technique to observe the effects of alloxan in the induction of diabetes mellitus. Twenty-four adult rabbits were divided into three study groups: control (C), diabetic (D) and diabetic associated to polytetrafluoroethylene (PTFE) membrane (D-PTFE). For diabetes induction the animals received one dose of monohydrated alloxan (90 mg/kg) by intravenous administration in the auricular or femoral vein. In group D-PTFE the membrane covered both the floor and the surface of the bone defect. In groups D and C, the bone defect was filled up with blood clot. The specimens were fixed in 10% formol and prepared for histomorphometric analysis. The results showed that the 90 mg/kg dose of monohydrate alloxan was sufficient to promote diabetes mellitus when administered in the auricular vein. Bone regeneration was slower in the diabetic group when compared with the control and diabetic-PTFE groups, but there was no significant statistical difference between the two experimental groups (D and D-PTFE). The oral and general clinical complications among the diabetics were weight loss, polyuria, polyphagia and severe chronic gingivitis.en
dc.description.affiliationOral Biopathology Program School of Dentistry of São Jose dos Campos São Paulo State University (UNESP), São Paulo
dc.description.affiliationSpecial Health Care Needs Association (ASPE) Bioscience Center for Special Health Care Needs (CEBAPE/UNESP) São Paulo State University (UNESP), São Paulo, SP
dc.description.affiliation, Av. Eng. Francisco José Lango, 777, São José dos Campos, SP 12245-000
dc.description.affiliationUnespOral Biopathology Program School of Dentistry of São Jose dos Campos São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespSpecial Health Care Needs Association (ASPE) Bioscience Center for Special Health Care Needs (CEBAPE/UNESP) São Paulo State University (UNESP), São Paulo, SP
dc.format.extent184-191
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242008000200015
dc.identifier.citationBrazilian Oral Research, v. 22, n. 2, p. 184-191, 2008.
dc.identifier.doi10.1590/S1806-83242008000200015
dc.identifier.file2-s2.0-48249138149.pdf
dc.identifier.issn1806-8324
dc.identifier.issn1807-3107
dc.identifier.lattes1274225455678400
dc.identifier.scieloS1806-83242008000200015
dc.identifier.scopus2-s2.0-48249138149
dc.identifier.urihttp://hdl.handle.net/11449/70520
dc.language.isoeng
dc.relation.ispartofBrazilian Oral Research
dc.relation.ispartofjcr1.223
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAlloxan
dc.subjectBone regeneration
dc.subjectDiabetes complications
dc.subjectDiabetes mellitus
dc.subjectalloxan
dc.subjectbiomaterial
dc.subjectpolitef
dc.subjectanalysis of variance
dc.subjectanimal
dc.subjectbone regeneration
dc.subjectchemically induced disorder
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectexperimental diabetes mellitus
dc.subjectpancreas
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectrabbit
dc.subjectrandomization
dc.subjectskull
dc.subjectwound healing
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBone Regeneration
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDisease Models, Animal
dc.subjectPancreas
dc.subjectParietal Bone
dc.subjectPolytetrafluoroethylene
dc.subjectRabbits
dc.subjectRandom Allocation
dc.subjectSkull
dc.subjectWound Healing
dc.titleBone regeneration in cranioplasty and clinical complications in rabbits with alloxan-induced diabetesen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bor/paboutj.htm
unesp.author.lattes1274225455678400
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Biociências e Diagnóstico Bucal - ICT