Artepillin C as an outstanding phenolic compound of Brazilian green propolis for disease treatment: A review on pharmacological aspects

Página do item simplificado
dc.contributor.authorBeserra, Fernando Pereira [UNESP]
dc.contributor.authorGushiken, Lucas Fernando Sérgio [UNESP]
dc.contributor.authorHussni, Maria Fernanda [UNESP]
dc.contributor.authorRibeiro, Victor Pena
dc.contributor.authorBonamin, Flávia
dc.contributor.authorJackson, Christopher John
dc.contributor.authorPellizzon, Cláudia Helena [UNESP]
dc.contributor.authorBastos, Jairo Kenupp
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAvaré Faculty (EDUVALE)
dc.contributor.institutionThe University of Sydney (USYD) at Royal North Shore Hospital
dc.date.accessioned2020-12-12T02:49:57Z
dc.date.available2020-12-12T02:49:57Z
dc.date.issued2020-01-01
dc.description.abstractPropolis is a viscous resin consisting of plant material (shoots, flowers, and plant exudates), salivary secretions and waxes produced by Apis mellifera bees. Its popular use aroused the interests of scientific research, which proved to be a potential source of various bioactive substances. The chemical composition of propolis depends on several factors, such as the different types of plant sources collected by bees, geographic origin, and the time of year in which they are produced, but it is known that phenolic represent the main bioactive constituents of propolis. Baccharis dracunculifolia DC (Asteraceae) is the most important botanical source of propolis and a native to southeastern Brazil. It is widely known as the green propolis because of its deep green color. One of its major phenolic acids is artepillin C (Art-C), a diprenyl-p-hydroxycinnamic acid derivative. This review aims to provide a comprehensive summary of the pharmacological effects of Art-C. The limited number of publications on this topic over the past two decades have been collected from databases and summarized. Numerous biological activities have been described for the Art-C, such as gastroprotective, anti-inflammatory, antimicrobial, antioxidant, antitumor. This article describes aspects of occurrence, synthesis, biological activities and pharmacokinetic approaches.en
dc.description.affiliationDepartment of Pharmaceutical Sciences School of Pharmaceutical Sciences University of São Paulo (USP)
dc.description.affiliationDepartment of Morphology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationAvaré Faculty (EDUVALE)
dc.description.affiliationKolling Institute of Medical Research The University of Sydney (USYD) at Royal North Shore Hospital
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1002/ptr.6875
dc.identifier.citationPhytotherapy Research.
dc.identifier.doi10.1002/ptr.6875
dc.identifier.issn1099-1573
dc.identifier.issn0951-418X
dc.identifier.lattes0019393779801069
dc.identifier.orcid0000-0002-4494-4180
dc.identifier.scopus2-s2.0-85090959126
dc.identifier.urihttp://hdl.handle.net/11449/202104
dc.language.isoeng
dc.relation.ispartofPhytotherapy Research
dc.sourceScopus
dc.subjectartepillin C
dc.subjectgreen propolis
dc.subjectpharmacological properties
dc.subjectphenolic compounds
dc.titleArtepillin C as an outstanding phenolic compound of Brazilian green propolis for disease treatment: A review on pharmacological aspectsen
dc.typeResenha
unesp.author.lattes0019393779801069[7]
unesp.author.orcid0000-0002-0498-4444[1]
unesp.author.orcid0000-0001-9143-3706[2]
unesp.author.orcid0000-0001-9607-5768[3]
unesp.author.orcid0000-0002-5015-2446[4]
unesp.author.orcid0000-0001-6072-4113[5]
unesp.author.orcid0000-0002-9234-9116[6]
unesp.author.orcid0000-0002-4494-4180[7]
unesp.author.orcid0000-0001-8641-9686[8]

Arquivos

Coleções

Artigos - Morfologia - IBB