Green Brazilian propolis action on macrophages and lymphoid organs of chronically stressed mice

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dc.contributor.authorMissima, Fabiane [UNESP]
dc.contributor.authorSforcin, Jose Mauricio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:51:08Z
dc.date.available2014-05-20T13:51:08Z
dc.date.issued2008-03-01
dc.description.abstractStress is a generic term that summarizes how psychosocial and environmental factors influence physical and mental well-being. The interaction between stress and immunity has been widely investigated, involving the neuroendocrine system and several organs. Assays using natural products in stress models deserve further investigation. Propolis immunomodulatory action has been mentioned and it has been the subject of scientific investigation in our laboratory. The aim of this study was to evaluate if and how propolis activated macrophages in BALB/c mice submitted to immobilization stress, as well as the histopathological analysis of the thymus, bone marrow, spleen and adrenal glands. Stressed mice showed a higher hydrogen peroxide (H2O2) generation by peritoneal macrophages, and propolis treatment potentiated H2O2 generation and inhibited nitric oxide (NO) production by these cells. Histopathological analysis showed no alterations in the thymus, bone marrow and adrenal glands, but increased germinal centers in the spleen. Propolis treatment counteracted the alterations found in the spleen of stressed mice. New research is being carried out in order to elucidate propolis immunomodulatory action during stress.en
dc.description.affiliationUNESP, Biosci Inst, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent71-75
dc.identifierhttp://dx.doi.org/10.1093/ecam/nel112
dc.identifier.citationEvidence-based Complementary and Alternative Medicine. Oxford: Oxford Univ Press, v. 5, n. 1, p. 71-75, 2008.
dc.identifier.doi10.1093/ecam/nel112
dc.identifier.fileWOS000254917600010.pdf
dc.identifier.issn1741-427X
dc.identifier.urihttp://hdl.handle.net/11449/18266
dc.identifier.wosWOS:000254917600010
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofjcr2.064
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectlymphoid organsen
dc.subjectmacrophagesen
dc.subjectpropolisen
dc.subjectstressen
dc.titleGreen Brazilian propolis action on macrophages and lymphoid organs of chronically stressed miceen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderOxford Univ Press
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB