CRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats

Página do item simplificado
dc.contributor.authorOliveira, Leandro A. [UNESP]
dc.contributor.authorAlmeida, Jeferson [UNESP]
dc.contributor.authorBenini, Ricardo [UNESP]
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCAR)
dc.date.accessioned2015-08-06T16:13:51Z
dc.date.available2015-08-06T16:13:51Z
dc.date.issued2015
dc.description.abstractThe corticotropin-releasing factor (CRF) is involved in behavioral and physiological responses to emotional stress throughits actioninseverallimbic structures,including the bednucleus ofthe stria terminalis (BNST). Nevertheless, the role of CRF1 and CRF2 receptors in the BNST in cardiovascular adjustments during aversive threat is unknown. Therefore, in the present study we investigated the involvement of CRF receptors within the BNST in cardiovascular responses evoked by acute restraint stress in rats. For this, we evaluated the effects of bilateral treatment of the BNST with selective agonists and antagonists of either CRF1 or CRF2 receptors in the arterial pressure and heart rate increase and the decrease in tail skin temperature induced by restraint stress. Microinjection of the selective CRF1 receptor antagonist CP376395 into the BNST reduced the pressor and tachycardiac responses caused by restraint. Conversely, BNST treatment with the selective CRF1 receptor agonist CRF increased restraint-evoked arterial pressure and HR responses and reduced the fall in tail skin temperature response. All effects of CRF were inhibited by local BNST pretreatment with CP376395. The selective CRF2 receptor antagonist antisalvagine-30 reduced the arterial pressure increase and the fall in tail skin temperature. The selective CRF2 receptor agonist urocortin-3 increased restraint-evoked pressor and tachycardiac responses and reduced the drop in cutaneous temperature. All effects of urocortin-3 were abolished by local BNST pretreatment with antisalvagine-30. These findings indicate an involvement of both CRF1 and CRF2 receptors in the BNST in cardiovascular adjustments during emotional stress.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau Km 01, Campus Universitário, CEP 14801902, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau Km 01, Campus Universitário, CEP 14801902, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/14376-0
dc.description.sponsorshipIdFAPESP: 2012/50549-6
dc.format.extent53-62
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S1043661815000511
dc.identifier.citationPharmacological Research, v. 95-96, p. 53-62, 2015.
dc.identifier.doi10.1016/j.phrs.2015.03.012
dc.identifier.issn1043-6618
dc.identifier.lattes1117432571971568
dc.identifier.urihttp://hdl.handle.net/11449/126065
dc.language.isoeng
dc.relation.ispartofPharmacological Research
dc.relation.ispartofjcr4.897
dc.relation.ispartofsjr1,811
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectAutonomic activityen
dc.subjectBed nucleus stria terminalis (BSNT)en
dc.subjectCorticotropin releasing factor receptorsen
dc.subjectEmotional stressen
dc.subjectExtended amygdalaen
dc.subjectNeuropeptidesen
dc.subjectUrocortinen
dc.titleCRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in ratsen
dc.typeArtigo
unesp.author.lattes1117432571971568[4]
unesp.author.orcid0000-0002-1942-858X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Coleções

Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR