Pre-Multidrug-Resistant Mycobacterium tuberculosis Infection Causing Fatal Enteric Disease in a Dog from a Family with History of Human Tuberculosis

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dc.contributor.authorRibeiro, M. G. [UNESP]
dc.contributor.authorLima, M. C.F. [UNESP]
dc.contributor.authorFranco, M. M.J. [UNESP]
dc.contributor.authorMegid, J. [UNESP]
dc.contributor.authorSoares, L. M. [UNESP]
dc.contributor.authorMachado, L. H.A. [UNESP]
dc.contributor.authorMiyata, M. [UNESP]
dc.contributor.authorPavan, F. R. [UNESP]
dc.contributor.authorHeinemann, M. B.
dc.contributor.authorSouza Filho, A. F.
dc.contributor.authorLara, G. H.B. [UNESP]
dc.contributor.authorSanches, O. C.
dc.contributor.authorSanches, C. D.C. [UNESP]
dc.contributor.authorListoni, F. J.P. [UNESP]
dc.contributor.authorPaes, A. C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Santo Amaro
dc.date.accessioned2018-12-11T17:04:00Z
dc.date.available2018-12-11T17:04:00Z
dc.date.issued2017-10-01
dc.description.abstractThis report describes a fatal case of a pet dog with major enteric signs owned by a family that has experienced cases of pulmonary tuberculosis (TB) in the household. Clinical and epidemiological aspects, imaging data, microbiological, haematological and histopathological examinations were assessed to diagnosis of disease. gyrB-RFLP, spoligotyping and MIRU-VNTR allowed molecular detection of M. tuberculosis strain from S family. The resazurin microtiter assay indicated that all isolates were resistant to isoniazid, ethambutol, ciprofloxacin, ofloxacin, streptomycin and amikacin. The public health concerns related to canine tuberculosis and risk of the dissemination by pets of M. tuberculosis pre-multidrug-resistant (PMD) to isoniazid, ethambutol and other first-line drugs used in human therapy of TB are discussed. We believe this to be the first report of PMD M. tuberculosis infection in a dog presenting mainly enteric manifestation, confirmed as S lineage by molecular methods, owned by a family in which TB has spread in the household for generations.en
dc.description.affiliationUNESP-Univ. Estadual Paulista Department of Veterinary Hygiene and Public Health School of Veterinary Medicine and Animal Sciences
dc.description.affiliationUNESP-Univ. Estadual Paulista Department of Clinics School of Veterinary Medicine and Animal Sciences
dc.description.affiliationLaboratory of Micobacteriology Faculty of Pharmacy UNESP
dc.description.affiliationDepartment of Preventive Veterinary Medicine and Animal Health University of São Paulo
dc.description.affiliationUNISA University of Santo Amaro
dc.description.affiliationUnespUNESP-Univ. Estadual Paulista Department of Veterinary Hygiene and Public Health School of Veterinary Medicine and Animal Sciences
dc.description.affiliationUnespUNESP-Univ. Estadual Paulista Department of Clinics School of Veterinary Medicine and Animal Sciences
dc.description.affiliationUnespLaboratory of Micobacteriology Faculty of Pharmacy UNESP
dc.format.extente4-e7
dc.identifierhttp://dx.doi.org/10.1111/tbed.12513
dc.identifier.citationTransboundary and Emerging Diseases, v. 64, n. 5, p. e4-e7, 2017.
dc.identifier.doi10.1111/tbed.12513
dc.identifier.issn1865-1682
dc.identifier.issn1865-1674
dc.identifier.scopus2-s2.0-84977518197
dc.identifier.urihttp://hdl.handle.net/11449/173178
dc.language.isoeng
dc.relation.ispartofTransboundary and Emerging Diseases
dc.relation.ispartofsjr1,147
dc.relation.ispartofsjr1,147
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectanthropozoonosis
dc.subjectcanine tuberculosis
dc.subjectenteric manifestation
dc.subjectmultidrug resistance
dc.subjectS family mycobacteria
dc.titlePre-Multidrug-Resistant Mycobacterium tuberculosis Infection Causing Fatal Enteric Disease in a Dog from a Family with History of Human Tuberculosisen
dc.typeArtigo
unesp.author.lattes3221552979448328[15]
unesp.author.orcid0000-0001-7774-927X[15]

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