Hormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease).

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dc.contributor.authorPimenta, W. P. [UNESP]
dc.contributor.authorPaula, F. J. [UNESP]
dc.contributor.authorDick-de-Paula, I. [UNESP]
dc.contributor.authorPiccinato, C. E. [UNESP]
dc.contributor.authorMonteiro, C. M. [UNESP]
dc.contributor.authorBrandão-Neto, J. [UNESP]
dc.contributor.authorKettelhut, I. C. [UNESP]
dc.contributor.authorFoss, M. C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:53:54Z
dc.date.available2022-04-28T19:53:54Z
dc.date.issued1992-01-01
dc.description.abstractA case of a 43-year-old nonobese woman with adiposis dolorosa (Dercum's disease) is reported. Muscle glucose uptake and oxidation before and after ingestion of 75 g of glucose were similar to control group values, although a greater insulin release (16,578 vs 6,242 +/- 1,136 microU/3 h) occurred simultaneously. In vitro studies of abdominal normal and painful subcutaneous adipose tissue of the patient revealed lower responsiveness to norepinephrine and lack of response to the antilipolytic effect of insulin in the painful adipose tissue (0.98 vs 1.43 microM FFA/10(6) cells at 5.0 microM of norepinephrine). The disease was not correlated with the HLA system and there were no alterations in hormonal secretion at the pituitary, adrenal, gonadal, and thyroid levels. These findings indicate the presence of peripheral insulin resistance in this patient with adiposis dolorosa.en
dc.description.affiliationDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista SP
dc.description.affiliationUnespDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista SP
dc.format.extent889-893
dc.identifier.citationBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 25, n. 9, p. 889-893, 1992.
dc.identifier.issn0100-879X
dc.identifier.scopus2-s2.0-0026959957
dc.identifier.urihttp://hdl.handle.net/11449/223947
dc.language.isoeng
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]
dc.sourceScopus
dc.titleHormonal and metabolic study of a case of adiposis dolorosa (Dercum's disease).en
dc.typeArtigo

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