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Hemoglobin I-Philadelphia [alpha 16 (A14) LYS→GLU] heterozygote among blood donors from Brazil

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dc.contributor.authorTorres, F. R. [UNESP]
dc.contributor.authorOndei, L. S. [UNESP]
dc.contributor.authorZamaro, P. J. A. [UNESP]
dc.contributor.authorSilva, R. U.
dc.contributor.authorCavasini, C. E.
dc.contributor.authorRossit, A. R. B.
dc.contributor.authorMachado, R. L. D.
dc.contributor.authorBonini-Domingos, C. R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBanco de Sangue do Estado do Acre
dc.contributor.institutionFaculdade de Medicina
dc.date.accessioned2015-09-10T12:33:20Z
dc.date.available2015-09-10T12:33:20Z
dc.date.issued2006-01-01
dc.description.abstractWe describe a heterozygous case of Hb I-Philadelphia [alpha 16 (A14) LYS-->GLU] in a blood donor from the Acre State Blood Bank, in the Brazilian Amazon region. We confirmed the mutation by electrophoretic and chromatographic methods and by DNA sequencing. A literature search showed that this is the first description of this alpha globin mutant in a Brazilian Caucasian group. We also emphasize the importance of the hemoglobin study in blood donors for the purpose of the genetic counseling and quality assurance of the blood to be transfused. Screening tests for hemoglobin mutants are also important for gathering anthropological information about the Brazilian population.en
dc.description.affiliationDepartamento de Biologia Laboratório de Hemoglobinas e Genética Das Doenças Hematológicas UNESP, S. José do Rio Preto, SP
dc.description.affiliationBanco de Sangue do Estado do Acre, Rio Branco, AC
dc.description.affiliationDepartamento de Doenças Infecciosas, Dermatológicas e Parasitárias Centro de Investigação de Microrganismos Faculdade de Medicina, S. José do Rio Preto, SP
dc.description.affiliationUnespDepartamento de Biologia Laboratório de Hemoglobinas e Genética Das Doenças Hematológicas UNESP, S. José do Rio Preto, SP
dc.format.extent713-716
dc.identifierhttp://www.geneticsmr.com/articles/307
dc.identifier.citationGenetics and Molecular Research, v. 5, n. 4, p. 713-716, 2006.
dc.identifier.fileWOS000203012000013.pdf
dc.identifier.issn1676-5680
dc.identifier.lattes9424175688206545
dc.identifier.lattes3279428066176719
dc.identifier.orcid0000-0002-4603-9467
dc.identifier.scopus2-s2.0-33845424973
dc.identifier.urihttp://hdl.handle.net/11449/38238
dc.identifier.wosWOS:000203012000013
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.sourceScopus
dc.subjectHb I-Philadelphiapt
dc.subjectrare hemoglobinpt
dc.subjectHPLCpt
dc.subjectblood donorspt
dc.titleHemoglobin I-Philadelphia [alpha 16 (A14) LYS→GLU] heterozygote among blood donors from Brazilen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/5
dcterms.rightsHolderFunpec-editora
dspace.entity.typePublication
unesp.author.lattes9424175688206545
unesp.author.lattes3279428066176719[8]
unesp.author.orcid0000-0002-4603-9467[8]
unesp.author.orcid0000-0002-0461-7521[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas