Publicação: Structural bioinformatics study of EPSP synthase from Mycobacterium tuberculosis
dc.contributor.author | Pereira, J. H. | |
dc.contributor.author | Canduri, F. | |
dc.contributor.author | de Oliveira, J. S. | |
dc.contributor.author | da Silveira, NJF | |
dc.contributor.author | Basso, L. A. | |
dc.contributor.author | Palma, Mario Sergio [UNESP] | |
dc.contributor.author | de Azevedo, W. F. | |
dc.contributor.author | Santos, D. S. | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Instituto Butantan | |
dc.contributor.institution | Universidade Federal do Rio Grande do Sul (UFRGS) | |
dc.contributor.institution | Pontificia Univ Catolica Rio Grande do Sul | |
dc.date.accessioned | 2014-05-20T13:54:19Z | |
dc.date.available | 2014-05-20T13:54:19Z | |
dc.date.issued | 2003-12-19 | |
dc.description.abstract | The shikimate pathway is an attractive target for herbicides and antimicrobial agent development because it is essential in algae, higher plants, bacteria, and fungi, but absent from mammals. Homologues to enzymes in the shikimate pathway have been identified in the genome sequence of Mycobacterium tuberculosis. Among them, the EPSP synthase was proposed to be present by sequence homology. Accordingly, in order to pave the way for structural and functional efforts towards anti-mycobacterial agent development, here we describe the molecular modeling of 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase isolated from M. tuberculosis that should provide a structural framework on which the design of specific inhibitors may be based on. Significant differences in the relative orientation of the domains in the two models result in open and closed conformations. The possible relevance of this structural transition in the ligand biding is discussed. (C) 2003 Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | UNESP, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | |
dc.description.affiliation | Inst Butantan, Ctr Appl Toxinol, BR-05503900 São Paulo, SP, Brazil | |
dc.description.affiliation | UFRGS, Dept Biol Mol & Biotecnol, Rede Brasileira Pesquisa Pesquisa TB Grp Microbio, BR-91501970 Porto Alegre, RS, Brazil | |
dc.description.affiliation | UNESP, CEIS, Dept Biol, Inst Biosci,Lab Struct Biol & Zoochem, BR-13506900 Rio Claro, SP, Brazil | |
dc.description.affiliation | Pontificia Univ Catolica Rio Grande do Sul, Fac Farm, Inst Pesquisas Biomed, Porto Alegre, RS, Brazil | |
dc.description.affiliationUnesp | UNESP, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, CEIS, Dept Biol, Inst Biosci,Lab Struct Biol & Zoochem, BR-13506900 Rio Claro, SP, Brazil | |
dc.format.extent | 608-614 | |
dc.identifier | http://dx.doi.org/10.1016/j.bbrc.2003.10.175 | |
dc.identifier.citation | Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc. Elsevier B.V., v. 312, n. 3, p. 608-614, 2003. | |
dc.identifier.doi | 10.1016/j.bbrc.2003.10.175 | |
dc.identifier.issn | 0006-291X | |
dc.identifier.lattes | 2901888624506535 | |
dc.identifier.uri | http://hdl.handle.net/11449/19408 | |
dc.identifier.wos | WOS:000187021300011 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | |
dc.relation.ispartofjcr | 2.559 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | EPSP synthase | pt |
dc.subject | bioinformatics | pt |
dc.subject | molecular modeling | pt |
dc.subject | Mycobacterium tuberculosis | pt |
dc.title | Structural bioinformatics study of EPSP synthase from Mycobacterium tuberculosis | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
dspace.entity.type | Publication | |
unesp.author.lattes | 2901888624506535 | |
unesp.author.orcid | 0000-0002-7363-8211[6] | |
unesp.author.orcid | 0000-0003-0903-2407[5] | |
unesp.author.orcid | 0000-0003-4971-463X[8] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claro | pt |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Preto | pt |
unesp.department | Biologia - IB | pt |
unesp.department | Física - IBILCE | pt |
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