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Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study

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dc.contributor.authorAlves, Mariana De Sá [UNESP]
dc.contributor.authorFugisaki, Luciana Ruano De Oliveira [UNESP]
dc.contributor.authorDos Santos, Jéssica Diane [UNESP]
dc.contributor.authorScorzoni, Liliana [UNESP]
dc.contributor.authorMedina, Rebeca Previate [UNESP]
dc.contributor.authorSilva, Dulce Helena Siqueira [UNESP]
dc.contributor.authorJunqueira, Juliana Campos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:30:53Z
dc.date.available2022-04-29T08:30:53Z
dc.date.issued2021-07-01
dc.description.abstractPrevious studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary: Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Sao Paulo State University (UNESP) Sao Jose Dos Campos
dc.description.affiliationDepartment of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Sao Paulo State University (UNESP) Sao Jose Dos Campos
dc.description.affiliationUnespDepartment of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP)
dc.format.extent744-747
dc.identifierhttp://dx.doi.org/10.1093/mmy/myab008
dc.identifier.citationMedical Mycology, v. 59, n. 7, p. 744-747, 2021.
dc.identifier.dimensionspub.1134894710
dc.identifier.doi10.1093/mmy/myab008
dc.identifier.issn1460-2709
dc.identifier.issn1369-3786
dc.identifier.orcid0000-0002-0178-6653
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.orcid0000-0002-3048-1138
dc.identifier.orcid0000-0002-0956-0747
dc.identifier.orcid0000-0001-6646-6856
dc.identifier.orcid0000-0003-0769-2938
dc.identifier.pmid33594432
dc.identifier.scopus2-s2.0-85110947772
dc.identifier.urihttp://hdl.handle.net/11449/229189
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.relation.ispartofMedical Mycology
dc.rights.accessRightsAcesso abertopt
dc.rights.sourceRightsoa_all
dc.rights.sourceRightsgreen
dc.sourceScopus
dc.sourceDimensions
dc.subjectCandida albicans
dc.subjectCandida glabrata
dc.subjectCandida krusei
dc.subjectGalleria mellonella
dc.subjectStreptococcus mutans
dc.titleAntifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo studyen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublicationc73b286a-b5fa-4312-a7ec-62f987e7b514
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, São José dos Campospt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBiociências e Diagnóstico Bucal - ICTpt
unesp.departmentQuímica Orgânica - IQARpt

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São José dos Campos - ICT - Instituto de Ciência e Tecnologia
Araraquara - IQAR - Instituto de Química