Publicação: Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study
| dc.contributor.author | Alves, Mariana De Sá [UNESP] | |
| dc.contributor.author | Fugisaki, Luciana Ruano De Oliveira [UNESP] | |
| dc.contributor.author | Dos Santos, Jéssica Diane [UNESP] | |
| dc.contributor.author | Scorzoni, Liliana [UNESP] | |
| dc.contributor.author | Medina, Rebeca Previate [UNESP] | |
| dc.contributor.author | Silva, Dulce Helena Siqueira [UNESP] | |
| dc.contributor.author | Junqueira, Juliana Campos [UNESP] | |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
| dc.date.accessioned | 2022-04-29T08:30:53Z | |
| dc.date.available | 2022-04-29T08:30:53Z | |
| dc.date.issued | 2021-07-01 | |
| dc.description.abstract | Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract. Lay Summary: Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model. | en |
| dc.description.affiliation | Department of Biosciences and Oral Diagnosis Institute of Science and Technology Sao Paulo State University (UNESP) Sao Jose Dos Campos | |
| dc.description.affiliation | Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP) | |
| dc.description.affiliationUnesp | Department of Biosciences and Oral Diagnosis Institute of Science and Technology Sao Paulo State University (UNESP) Sao Jose Dos Campos | |
| dc.description.affiliationUnesp | Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP) | |
| dc.format.extent | 744-747 | |
| dc.identifier | http://dx.doi.org/10.1093/mmy/myab008 | |
| dc.identifier.citation | Medical Mycology, v. 59, n. 7, p. 744-747, 2021. | |
| dc.identifier.doi | 10.1093/mmy/myab008 | |
| dc.identifier.issn | 1460-2709 | |
| dc.identifier.issn | 1369-3786 | |
| dc.identifier.scopus | 2-s2.0-85110947772 | |
| dc.identifier.uri | http://hdl.handle.net/11449/229189 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Medical Mycology | |
| dc.source | Scopus | |
| dc.subject | Candida albicans | |
| dc.subject | Candida glabrata | |
| dc.subject | Candida krusei | |
| dc.subject | Galleria mellonella | |
| dc.subject | Streptococcus mutans | |
| dc.title | Antifungal effects of Streptococcus mutans extract on Candida strains susceptible and resistant to fluconazole: An in vivo study | en |
| dc.type | Artigo | |
| dspace.entity.type | Publication | |
| unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, São José dos Campos | pt |
| unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Química, Araraquara | pt |
| unesp.department | Biociências e Diagnóstico Bucal - ICT | pt |
| unesp.department | Química Orgânica - IQAR | pt |