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Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses

dc.contributor.authorPimenta, E. L. M. [UNESP]
dc.contributor.authorTeixeira Neto, Francisco José [UNESP]
dc.contributor.authorSa, P. A. [UNESP]
dc.contributor.authorPignaton, W. [UNESP]
dc.contributor.authorGarofalo, N. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:13Z
dc.date.available2014-05-20T15:32:13Z
dc.date.issued2011-05-01
dc.description.abstractP>Reasons for performing study:Bradycardia may be implicated as a cause of cardiovascular instability during anaesthesia.Hypothesis:Hyoscine would induce positive chronotropism of shorter duration than atropine, without adversely impairing intestinal motility in detomidine sedated horses.Methods:Ten minutes after detomidine (0.02 mg/kg bwt, i.v.), physiological saline (control), atropine (0.02 mg/kg bwt) or hyoscine (0.2 mg/kg bwt) were randomly administered i.v. to 6 horses, allowing one week intervals between treatments. Investigators blinded to the treatments monitored cardiopulmonary data and intestinal auscultation for 90 min and 24 h after detomidine, respectively. Gastrointestinal transit was assessed for 96 h via chromium detection in dry faeces.Results:Detomidine significantly decreased heart rate (HR) and cardiac index (CI) from baseline for 30 and 60 min, respectively (control). Mean +/- s.d. HR increased significantly 5 min after atropine (79 +/- 5 beats/min) and hyoscine (75 +/- 8 beats/min). After this time, HR was significantly higher after atropine in comparison to other treatments, while hyoscine resulted in intermediate values (lower than atropine but higher than controls). Hyoscine and atropine resulted in significantly higher CI than controls for 5 and 20 min, respectively; but this effect coincided with significant hypertension (mean arterial pressures > 180 mmHg). Auscultation scores decreased from baseline in all treatments. Time to return to auscultation scores >= 12 (medians) did not differ between hyoscine (4 h) and controls (4 h) but atropine resulted in significantly longer time (10 h). Atropine induced colic in one horse. Gastrointestinal transit times did not differ between treatments.Conclusion:Hyoscine is a shorter acting positive chronotropic agent than atropine, but does not potentiate the impairment in intestinal motility induced by detomidine. Because of severe hypertension, routine use of anticholinergics combined with detomidine is not recommended.Potencial relevance:Hyoscine may represent an alternative to atropine for treating bradycardia.en
dc.description.affiliationUniv Estadual Paulista, Fac Med Vet & Zootecnia, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Vet & Zootecnia, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 07/53509-7
dc.description.sponsorshipIdFAPESP: 08/50301-9
dc.description.sponsorshipIdCNPq: 303745/2008-8
dc.format.extent332-340
dc.identifierhttp://dx.doi.org/10.1111/j.2042-3306.2010.00165.x
dc.identifier.citationEquine Veterinary Journal. Malden: Wiley-blackwell, v. 43, n. 3, p. 332-340, 2011.
dc.identifier.doi10.1111/j.2042-3306.2010.00165.x
dc.identifier.issn0425-1644
dc.identifier.urihttp://hdl.handle.net/11449/41174
dc.identifier.wosWOS:000289523600013
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofEquine Veterinary Journal
dc.relation.ispartofjcr2.022
dc.relation.ispartofsjr0,991
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecthorseen
dc.subjectdetomidineen
dc.subjectatropineen
dc.subjecthyoscineen
dc.subjectanaesthesiaen
dc.subjectgastrointestinal motilityen
dc.titleComparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horsesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
dspace.entity.typePublication
unesp.author.orcid0000-0002-3002-8093[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentCirurgia e Anestesiologia Veterinária - FMVZpt

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