DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
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Date
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Coadvisor
Graduate program
Undergraduate course
Journal Title
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Publisher
Biomed Central Ltd
Type
Article
Access right
Acesso aberto
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Abstract
Background: Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods: DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results: The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion: These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
Description
Keywords
Jorge Lobo'disease, Lacazia loboi, Malnutrition, Mice, Genotoxicity, Comet assay
Language
English
Citation
Journal Of Venomous Animals And Toxins Including Tropical Diseases, London, v. 21, 5 p., 2015.
