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Inactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challenge

dc.contributor.authorLopes, Priscila Diniz [UNESP]
dc.contributor.authorOkino, Cintia Hiromi
dc.contributor.authorFernando, Filipe Santos [UNESP]
dc.contributor.authorPavani, Caren [UNESP]
dc.contributor.authorCasagrande, Viviane Mariguela [UNESP]
dc.contributor.authorLopez, Renata F.V.
dc.contributor.authorMontassier, Maria de Fátima Silva [UNESP]
dc.contributor.authorMontassier, Helio José [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:36:36Z
dc.date.available2018-12-11T17:36:36Z
dc.date.issued2018-05-03
dc.description.abstractAvian infectious bronchitis virus (IBV) is one of the most important viral diseases of poultry. The mucosa of upper respiratory tract, specially the trachea, is the primary replication site for this virus. However, conventional inactivate IBV vaccines usually elicit reduced mucosal immune responses and local protection. Thus, an inactivated IBV vaccine containing BR-I genotype strain encapsulated in chitosan nanoparticles (IBV-CS) was produced by ionic gelation method to be administered by oculo-nasal route to chickens. IBV-CS vaccine administered alone resulted in markedly mucosal immune responses, characterized by high levels of anti-IBV IgA isotype antibodies and IFNγ gene expression at 1dpi. The association of live attenuated Massachusetts IBV and IBV-CS vaccine also induced strong mucosal immune responses, though a switch from IgA isotype to IgG was observed, and IFNγ gene expression peak was late (at 5 dpi). Efficacy of IBV-CS was evaluated by tracheal ciliostasis analysis, histopathology examination, and viral load determination in the trachea and kidney. The results indicated that IBV-CS vaccine administered alone or associated with a live attenuated heterologous vaccine induced both humoral and cell-mediated immune responses at the primary site of viral replication, and provided an effective protection against IBV infection at local (trachea) and systemic (kidney) sites.en
dc.description.affiliationFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castelane, S/N – Vila Industrial, Jaboticabal
dc.description.affiliationEmbrapa Pecuária Sudeste Empresa Brasileira de Pesquisa Agropecuária (Embrapa), Rodovia Washington Luiz, Km 234 s/n – Fazenda Canchim, São Carlos
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo (USP), Avenida Bandeirantes, 3.900 – Monte Alegre, Ribeirão Preto
dc.description.affiliationUnespFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castelane, S/N – Vila Industrial, Jaboticabal
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 140100/2015-6
dc.format.extent2630-2636
dc.identifierhttp://dx.doi.org/10.1016/j.vaccine.2018.03.065
dc.identifier.citationVaccine, v. 36, n. 19, p. 2630-2636, 2018.
dc.identifier.doi10.1016/j.vaccine.2018.03.065
dc.identifier.file2-s2.0-85045124096.pdf
dc.identifier.issn1873-2518
dc.identifier.issn0264-410X
dc.identifier.scopus2-s2.0-85045124096
dc.identifier.urihttp://hdl.handle.net/11449/179751
dc.language.isoeng
dc.relation.ispartofVaccine
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAvian infectious bronchitis virus
dc.subjectBR-I genotype
dc.subjectChitosan nanoparticles
dc.subjectInactivated vaccine
dc.subjectMucosal immune responses
dc.titleInactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challengeen
dc.typeArtigo
dspace.entity.typePublication
unesp.departmentPatologia Veterinária - FCAVpt

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