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Validation of microbiological assay for determination of cefuroxime in injectable preparations

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dc.contributor.authorVieira, Daniela C.M. [UNESP]
dc.contributor.authorRicarte, Patrícia C. [UNESP]
dc.contributor.authorSalgado, Hérida R.N. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:56Z
dc.date.available2014-05-27T11:26:56Z
dc.date.issued2012-08-22
dc.description.abstractThe validation of a microbiological assay, applying agar diffusion method for determination of the active of cefuroxime in power for injection, is described. Using a strain of Micrococcus luteus ATCC 9341 as the test organism, cefuroxime was measured in concentrations ranging from 30.0 to 120.0 μg/mL. The method validation showed that it is linear (r = 0.9999), precise (relative standard deviation = 0.37%) and accurate (it measured the added quantities). Microbiological assay is satisfactory for quantitation of cefuroxime in powder for injection and the validity of the proposed bioassay, which is a simple and a useful alternative methodology for cefuroxime determination in routine quality control.en
dc.description.affiliationCiências Farmacêuticas de Araraquara Unesp, Rodovia Araraquara-Jaú, km 1, CEP: 14801-902 Araraquara-SP
dc.description.affiliationUnespCiências Farmacêuticas de Araraquara Unesp, Rodovia Araraquara-Jaú, km 1, CEP: 14801-902 Araraquara-SP
dc.format.extent746-750
dc.identifierhttp://www.latamjpharm.org/resumenes/31/5/LAJOP_31_5_2_2.pdf
dc.identifier.citationLatin American Journal of Pharmacy, v. 31, n. 5, p. 746-750, 2012.
dc.identifier.issn0326-2383
dc.identifier.scopus2-s2.0-84865083152
dc.identifier.urihttp://hdl.handle.net/11449/73510
dc.language.isoeng
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.ispartofjcr0.401
dc.relation.ispartofsjr0,152
dc.rights.accessRightsAcesso restritopt
dc.sourceScopus
dc.subjectCefuroxime
dc.subjectCephalosporins
dc.subjectMicrobiological assay
dc.subjectQuality control
dc.subjectValidation
dc.subjectcefuroxime
dc.subjectagar diffusion
dc.subjectbacterial growth
dc.subjectbacterial strain
dc.subjectbacterium culture
dc.subjectcalibration
dc.subjectcorrelation coefficient
dc.subjectdrug determination
dc.subjectdrug purity
dc.subjectdrug structure
dc.subjectlimit of detection
dc.subjectlimit of quantitation
dc.subjectmicrobiology
dc.subjectMicrococcus luteus
dc.subjectquality control
dc.subjectvalidation study
dc.titleValidation of microbiological assay for determination of cefuroxime in injectable preparationsen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas