Free radical production by azomethine H: Effects on pancreatic and hepatic tissues
Carregando...
Fontes externas
Fontes externas
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Taylor & Francis
Tipo
Artigo
Direito de acesso
Acesso restrito
Fontes externas
Fontes externas
Resumo
The antimalarial properties of azomethine H represent the basis for its use as a chemotherapeutic agent. This work was carried out in order to verify the biological side effects of azomethine H and to clarify the contribution of reactive oxygen species (ROS) in this process. It was shown that azomethine H increased serum activities of amylase, alanine transaminase (ALT) and the TEARS concentrations, in rats. No changes were observed in glutathione peroxidase and catalase activities. The drug-induced tissue damage might be due to superoxide radicals (O-2(.-)), since Cu-Zn superoxide dismutase activities were increased by azomethine I-I treatment. This study allows tentative conclusions to be drawn regarding which reactive oxygen metabolites play a role in azomethine H activity. We concluded that (O-2(.-)) maybe produced as a mediator of azomethine H action.
Descrição
Palavras-chave
Azomethine H , Cu-Zn superoxide dismutase , Glutathione peroxidase , Superoxide radical , Toxicity , alanine aminotransferase , amylase , antimalarial agent , azomethine h , catalase , copper zinc superoxide dismutase , free radical , glutathione peroxidase , reactive oxygen metabolite , superoxide , thiobarbituric acid reactive substance , unclassified drug , alanine aminotransferase blood level , amylase blood level , animal experiment , animal tissue , controlled study , dose response , enzyme activity , intraperitoneal drug administration , male , nonhuman , rat , tissue injury , Alanine Transaminase , Amylases , Animals , Antimalarials , Catalase , Dose-Response Relationship, Drug , Free Radicals , Glutathione Peroxidase , Liver , Male , Naphthalenesulfonates , Pancreas , Rats , Rats, Wistar , Reactive Oxygen Species , Superoxide Dismutase , Superoxides , Thiobarbituric Acid Reactive Substances , Thiosemicarbazones , Animalia
Idioma
Inglês
Citação
Free Radical Research, v. 26, n. 4, p. 319-324, 1997.
