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Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer

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dc.contributor.authorStrakova, Andrea
dc.contributor.authorNicholls, Thomas J.
dc.contributor.authorBaez-Ortega, Adrian
dc.contributor.authorNí Leathlobhair, Máire
dc.contributor.authorSampson, Alexander T.
dc.contributor.authorHughes, Katherine
dc.contributor.authorBolton, Isobelle A. G.
dc.contributor.authorGori, Kevin
dc.contributor.authorWang, Jinhong
dc.contributor.authorAirikkala-Otter, Ilona
dc.contributor.authorAllen, Janice L.
dc.contributor.authorAllum, Karen M.
dc.contributor.authorArnold, Clara L.
dc.contributor.authorBansse-Issa, Leontine
dc.contributor.authorBhutia, Thinlay N.
dc.contributor.authorBisson, Jocelyn L.
dc.contributor.authorBlank, Kelli
dc.contributor.authorBriceño, Cristóbal
dc.contributor.authorCastillo Domracheva, Artemio
dc.contributor.authorCorrigan, Anne M.
dc.contributor.authorCran, Hugh R.
dc.contributor.authorCrawford, Jane T.
dc.contributor.authorCutter, Stephen M.
dc.contributor.authorDavis, Eric
dc.contributor.authorde Castro, Karina F.
dc.contributor.authorDe Nardi, Andrigo B. [UNESP]
dc.contributor.authorde Vos, Anna P.
dc.contributor.authorDelgadillo Keenan, Laura
dc.contributor.authorDonelan, Edward M.
dc.contributor.authorEspinoza Huerta, Adela R.
dc.contributor.authorFaramade, Ibikunle A.
dc.contributor.authorFazil, Mohammed
dc.contributor.authorFotopoulou, Eleni
dc.contributor.authorFruean, Skye N.
dc.contributor.authorGallardo-Arrieta, Fanny
dc.contributor.authorGlebova, Olga
dc.contributor.authorGouletsou, Pagona G.
dc.contributor.authorHäfelin Manrique, Rodrigo F.
dc.contributor.authorHenriques, Joaquim J. G. P.
dc.contributor.authorHorta, Rodrigo S.
dc.contributor.authorIgnatenko, Natalia
dc.contributor.authorKane, Yaghouba
dc.contributor.authorKing, Cathy
dc.contributor.authorKoenig, Debbie
dc.contributor.authorKrupa, Ada
dc.contributor.authorKruzeniski, Steven J.
dc.contributor.authorLanza-Perea, Marta
dc.contributor.authorLazyan, Mihran
dc.contributor.authorLopez Quintana, Adriana M.
dc.contributor.authorLosfelt, Thibault
dc.contributor.authorMarino, Gabriele
dc.contributor.authorMartínez Castañeda, Simón
dc.contributor.authorMartínez-López, Mayra F.
dc.contributor.authorMasuruli, Bedan M.
dc.contributor.authorMeyer, Michael
dc.contributor.authorMigneco, Edward J.
dc.contributor.authorNakanwagi, Berna
dc.contributor.authorNeal, Karter B.
dc.contributor.authorNeunzig, Winifred
dc.contributor.authorNixon, Sally J.
dc.contributor.authorOrtega-Pacheco, Antonio
dc.contributor.authorPedraza-Ordoñez, Francisco
dc.contributor.authorPeleteiro, Maria C.
dc.contributor.authorPolak, Katherine
dc.contributor.authorPye, Ruth J.
dc.contributor.authorRamirez-Ante, Juan C.
dc.contributor.authorReece, John F.
dc.contributor.authorRojas Gutierrez, Jose
dc.contributor.authorSadia, Haleema
dc.contributor.authorSchmeling, Sheila K.
dc.contributor.authorShamanova, Olga
dc.contributor.authorSherlock, Alan G.
dc.contributor.authorSteenland-Smit, Audrey E.
dc.contributor.authorSvitich, Alla
dc.contributor.authorTapia Martínez, Lester J.
dc.contributor.authorThoya Ngoka, Ismail
dc.contributor.authorTorres, Cristian G.
dc.contributor.authorTudor, Elizabeth M.
dc.contributor.authorvan der Wel, Mirjam G.
dc.contributor.authorVițălaru, Bogdan A.
dc.contributor.authorVural, Sevil A.
dc.contributor.authorWalkinton, Oliver
dc.contributor.authorWehrle-Martinez, Alvaro S.
dc.contributor.authorWiddowson, Sophie A. E.
dc.contributor.authorZvarich, Irina
dc.contributor.authorChinnery, Patrick F.
dc.contributor.authorFalkenberg, Maria
dc.contributor.authorGustafsson, Claes M.
dc.contributor.authorMurchison, Elizabeth P.
dc.contributor.institutionUniversity of Cambridge
dc.contributor.institutionUniversity of Gothenburg
dc.contributor.institutionNewcastle University
dc.contributor.institutionInternational Training Center
dc.contributor.institutionAnimal Management in Rural and Remote Indigenous Communities (AMRRIC)
dc.contributor.institutionWorld Vets
dc.contributor.institutionHopkins Belize Humane Society
dc.contributor.institutionStichting Dierenbescherming Suriname
dc.contributor.institutionGovernment of Sikkim
dc.contributor.institutionUniversity of Chile
dc.contributor.institutionUniversity of Panamá
dc.contributor.institutionSt. George’s University
dc.contributor.institutionThe Nakuru District Veterinary Scheme Ltd
dc.contributor.institutionAnimal Medical Centre
dc.contributor.institutionUC Davis School of Veterinary Medicine
dc.contributor.institutionSão José do Rio Preto
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLadybrand Animal Clinic
dc.contributor.institutionVeterinary Clinic Sr. Dog’s
dc.contributor.institutionWorld Vets Latin America Veterinary Training Center
dc.contributor.institutionNational Veterinary Research Institute
dc.contributor.institutionAnimal Clinic
dc.contributor.institutionIntermunicipal Stray Animals Care Centre (DIKEPAZ)
dc.contributor.institutionAnimal Protection Society of Samoa
dc.contributor.institutionUniversity of Zulia
dc.contributor.institutionVeterinary Clinic BIOCONTROL
dc.contributor.institutionUniversity of Thessaly
dc.contributor.institutionHospital Veterinário Berna
dc.contributor.institutionUniversidade Vila Velha
dc.contributor.institutionVeterinary Clinic Zoovetservis
dc.contributor.institutionÉcole Inter-états des Sciences et Médecine Vétérinaires de Dakar
dc.contributor.institutionUtrecht University
dc.contributor.institutionVetexpert Veterinary Group
dc.contributor.institutionLopez Quintana Veterinary Clinic
dc.contributor.institutionSaint Gilles les Bains
dc.contributor.institutionUniversity of Messina
dc.contributor.institutionUniversidad Autónoma del Estado de México
dc.contributor.institutionUniversidad de las Américas
dc.contributor.institutionVeterinary Council of Tanzania
dc.contributor.institutionTouray & Meyer Vet Clinic
dc.contributor.institutionHillside Animal Hospital
dc.contributor.institutionThe Kampala Veterinary Surgery
dc.contributor.institutionAsavet Veterinary Charities
dc.contributor.institutionVets Beyond Borders
dc.contributor.institutionAutonomous University of Yucatan
dc.contributor.institutionUniversidad de Caldas
dc.contributor.institutionUniversity of Lisbon
dc.contributor.institutionFour Paws International
dc.contributor.institutionHelp in Suffering
dc.contributor.institutionVeterinary Clinic Dr José Rojas
dc.contributor.institutionEngineering and Management Sciences
dc.contributor.institutionCorozal Veterinary Clinic
dc.contributor.institutionVeterinary Clinic Vetmaster
dc.contributor.institutionState Hospital of Veterinary Medicine
dc.contributor.institutionJomo Kenyatta University of Agriculture and Technology
dc.contributor.institutionUniversity of Melbourne
dc.contributor.institutionAnimal Anti Cruelty League
dc.contributor.institutionFaculty of Veterinary Medicine Bucharest
dc.contributor.institutionAnkara University
dc.contributor.institutionNational University of Asuncion
dc.contributor.institutionLilongwe Society for Protection and Care of Animals (LSPCA)
dc.contributor.institutionVeterinary clinic Canine Heart
dc.date.accessioned2020-12-12T01:27:49Z
dc.date.available2020-12-12T01:27:49Z
dc.date.issued2020-12-01
dc.description.abstractAutonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.en
dc.description.affiliationTransmissible Cancer Group Department of Veterinary Medicine University of Cambridge
dc.description.affiliationDepartment of Medical Biochemistry and Cell Biology University of Gothenburg
dc.description.affiliationWellcome Centre for Mitochondrial Research Newcastle University
dc.description.affiliationDepartment of Veterinary Medicine University of Cambridge
dc.description.affiliationWorldwide Veterinary Service International Training Center
dc.description.affiliationAnimal Management in Rural and Remote Indigenous Communities (AMRRIC)
dc.description.affiliationWorld Vets
dc.description.affiliationHopkins Belize Humane Society
dc.description.affiliationAnimal Shelter Stichting Dierenbescherming Suriname
dc.description.affiliationSikkim Anti-Rabies and Animal Health Programme Department of Animal Husbandry Livestock Fisheries and Veterinary Services Government of Sikkim
dc.description.affiliationConserLab Animal Preventive Medicine Department Faculty of Animal and Veterinary Sciences University of Chile
dc.description.affiliationCorozal Veterinary Hospital University of Panamá
dc.description.affiliationSt. George’s University
dc.description.affiliationThe Nakuru District Veterinary Scheme Ltd
dc.description.affiliationAnimal Medical Centre
dc.description.affiliationInternational Animal Welfare Training Institute UC Davis School of Veterinary Medicine
dc.description.affiliationCentro Universitário de Rio Preto (UNIRP) São José do Rio Preto
dc.description.affiliationSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP)
dc.description.affiliationLadybrand Animal Clinic
dc.description.affiliationVeterinary Clinic Sr. Dog’s
dc.description.affiliationWorld Vets Latin America Veterinary Training Center
dc.description.affiliationNational Veterinary Research Institute
dc.description.affiliationAnimal Clinic
dc.description.affiliationIntermunicipal Stray Animals Care Centre (DIKEPAZ)
dc.description.affiliationAnimal Protection Society of Samoa
dc.description.affiliationFaculty of Veterinary Science University of Zulia
dc.description.affiliationVeterinary Clinic BIOCONTROL
dc.description.affiliationFaculty of Veterinary Medicine School of Health Sciences University of Thessaly
dc.description.affiliationVeterinary Clinic El Roble Animal Healthcare Network Faculty of Animal and Veterinary Sciences University of Chile
dc.description.affiliationOnevetGroup Hospital Veterinário Berna
dc.description.affiliationUniversidade Vila Velha
dc.description.affiliationVeterinary Clinic Zoovetservis
dc.description.affiliationÉcole Inter-états des Sciences et Médecine Vétérinaires de Dakar
dc.description.affiliationDepartment of Small Animal Medicine Faculty of Veterinary Medicine Utrecht University
dc.description.affiliationVetexpert Veterinary Group
dc.description.affiliationLopez Quintana Veterinary Clinic
dc.description.affiliationClinique Veterinaire de Grand Fond Saint Gilles les Bains
dc.description.affiliationDepartment of Veterinary Sciences University of Messina
dc.description.affiliationFacultad de Medicina Veterinaria y Zootecnia Universidad Autónoma del Estado de México
dc.description.affiliationSchool of Veterinary Medicine Universidad de las Américas
dc.description.affiliationVeterinary Council of Tanzania
dc.description.affiliationTouray & Meyer Vet Clinic
dc.description.affiliationHillside Animal Hospital
dc.description.affiliationThe Kampala Veterinary Surgery
dc.description.affiliationAsavet Veterinary Charities
dc.description.affiliationVets Beyond Borders
dc.description.affiliationFaculty of Veterinary Medicine Autonomous University of Yucatan
dc.description.affiliationLaboratorio de Patología Veterinaria Universidad de Caldas
dc.description.affiliationCentre for Interdisciplinary Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon
dc.description.affiliationFour Paws International
dc.description.affiliationHelp in Suffering
dc.description.affiliationVeterinary Clinic Dr José Rojas
dc.description.affiliationDepartment of Biotechnology Balochistan University of Information Technology Engineering and Management Sciences
dc.description.affiliationCorozal Veterinary Clinic
dc.description.affiliationVeterinary Clinic Vetmaster
dc.description.affiliationState Hospital of Veterinary Medicine
dc.description.affiliationJomo Kenyatta University of Agriculture and Technology
dc.description.affiliationLaboratory of Biomedicine and Regenerative Medicine Department of Clinical Sciences Faculty of Animal and Veterinary Sciences University of Chile
dc.description.affiliationFaculty of Veterinary and Agricultural Sciences University of Melbourne
dc.description.affiliationAnimal Anti Cruelty League
dc.description.affiliationClinical Sciences Department Faculty of Veterinary Medicine Bucharest
dc.description.affiliationDepartment of Pathology Faculty of Veterinary Medicine Ankara University
dc.description.affiliationFaculty of Veterinary Sciences National University of Asuncion
dc.description.affiliationLilongwe Society for Protection and Care of Animals (LSPCA)
dc.description.affiliationVeterinary clinic Canine Heart
dc.description.affiliationMRC-Mitochondrial Biology Unit & Department of Clinical Neurosciences University of Cambridge
dc.description.affiliationUnespSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1038/s41467-020-16765-w
dc.identifier.citationNature Communications, v. 11, n. 1, 2020.
dc.identifier.doi10.1038/s41467-020-16765-w
dc.identifier.issn2041-1723
dc.identifier.scopus2-s2.0-85086571979
dc.identifier.urihttp://hdl.handle.net/11449/198994
dc.language.isoeng
dc.relation.ispartofNature Communications
dc.sourceScopus
dc.titleRecurrent horizontal transfer identifies mitochondrial positive selection in a transmissible canceren
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication3d807254-e442-45e5-a80b-0f6bf3a26e48
relation.isOrgUnitOfPublication.latestForDiscovery3d807254-e442-45e5-a80b-0f6bf3a26e48
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unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias