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Environmental photochemical fate and UVC degradation of sodium levothyroxine in aqueous medium

dc.contributor.authorParizi, Marcela Prado Silva [UNESP]
dc.contributor.authorLastre Acosta, Arlen Mabel
dc.contributor.authorIshiki, Hamilton Mitsugu
dc.contributor.authorRossi, Renata Calciolari
dc.contributor.authorMafra, Renata Cristina
dc.contributor.authorTeixeira, Antonio Carlos Silva Costa
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity of Western São Paulo (Unoeste)
dc.date.accessioned2018-12-11T16:55:00Z
dc.date.available2018-12-11T16:55:00Z
dc.date.issued2018-01-01
dc.description.abstractThe synthetic hormone sodium levothyroxine (LTX) is one of the most prescribed drugs in the world and the most effective in hypothyroidism treatment. The presence of LTX in the environment has become a matter of major concern due to the widespread use of this hormone and by the fact that it is only partially removed in conventional water and sewage treatment plants. However, information regarding the photochemical fate of this hormone in environmental or engineered systems is scarce in the literature. In this work, the sunlight-driven direct and indirect LTX degradation was investigated by determining the photolysis quantum yield, ΦLTX = 3.80 (± 0.02) × 10−5, as well as the second-order kinetic constants of the reactions with hydroxyl radicals, kLTX,•OH = 1.50 (± 0.01) × 1010 L mol−1 s−1 and singlet oxygen, kLTX,1O2 = 1.47 (± 0.66) × 108 L mol−1 s−1. Mathematical simulations indicate that LTX photodegradation is favored in shallow, nitrite-rich, and dissolved organic matter (DOM)-poor environments, with LTX half-life times varying from less than 10 days to about 80 days. LTX removals of 85 and 95% were achieved by UVC photolysis and UVC/H2O2 after 120 min, respectively. Three transformation products, triiodothyronine, diiodothyronine, and diiodotyrosine, were identified during LTX degradation by the UVC-based processes studied. The results herein regarding photo-induced kinetics coupled with environmental fate simulations may help evaluate LTX persistence and also the design of water and wastewater treatment processes.en
dc.description.affiliationEnergy Engineering Department São Paulo State University (UNESP), Barrageiros Av. 1881
dc.description.affiliationResearch Group in Advanced Oxidation Processes Chemical Systems Engineering Center Department of Chemical Engineering University of São Paulo, Av. Prof. Luciano Gualberto, tr. 3, 380
dc.description.affiliationEnvironment and Regional Development University of Western São Paulo (Unoeste)
dc.description.affiliationUnespEnergy Engineering Department São Paulo State University (UNESP), Barrageiros Av. 1881
dc.identifierhttp://dx.doi.org/10.1007/s11356-018-2907-0
dc.identifier.citationEnvironmental Science and Pollution Research.
dc.identifier.doi10.1007/s11356-018-2907-0
dc.identifier.file2-s2.0-85051842409.pdf
dc.identifier.issn1614-7499
dc.identifier.issn0944-1344
dc.identifier.lattes0369255510931164
dc.identifier.scopus2-s2.0-85051842409
dc.identifier.urihttp://hdl.handle.net/11449/171359
dc.language.isoeng
dc.relation.ispartofEnvironmental Science and Pollution Research
dc.relation.ispartofsjr0,858
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectAdvanced oxidation processes
dc.subjectEndocrine disruptors
dc.subjectEnvironmental photochemical fate
dc.subjectMathematical simulations
dc.subjectReactive oxygen species
dc.subjectSodium levothyroxine
dc.titleEnvironmental photochemical fate and UVC degradation of sodium levothyroxine in aqueous mediumen
dc.typeArtigopt
dspace.entity.typePublication
unesp.author.lattes0369255510931164
unesp.author.orcid0000-0002-4159-8016[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Engenharia e Ciências, Rosanapt

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