Understanding the Structure, Activity and Inhibition of Chorismate Synthase from Mycobacterium tuberculosis
Loading...
External sources
External sources
Date
Authors
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Bentham Science Publ Ltd
Type
Review
Access right
Acesso restrito
External sources
External sources
Abstract
Tuberculosis is considered a worldwide health problem mainly due to co-infection with HIV and proliferation of multi-drug-resistant strains. The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria, but absent from mammals. The last step in this pathway is performed by chorismate synthase (CS), which catalyzes the conversion of 5-enolpyruvylshikimate-3-phosphate (EPSP) to chorismate. The aim of this article is to review the available information on chorismate synthase from Mycobacterium tuberculosis.
Description
Language
English
Citation
Current Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 18, n. 9, p. 1311-1317, 2011.
