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Understanding the Structure, Activity and Inhibition of Chorismate Synthase from Mycobacterium tuberculosis

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dc.contributor.authorArcuri, H. A. [UNESP]
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNatl Inst Sci & Technol Immunol INCT III
dc.date.accessioned2014-05-20T13:55:06Z
dc.date.available2014-05-20T13:55:06Z
dc.date.issued2011-03-01
dc.description.abstractTuberculosis is considered a worldwide health problem mainly due to co-infection with HIV and proliferation of multi-drug-resistant strains. The enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria, but absent from mammals. The last step in this pathway is performed by chorismate synthase (CS), which catalyzes the conversion of 5-enolpyruvylshikimate-3-phosphate (EPSP) to chorismate. The aim of this article is to review the available information on chorismate synthase from Mycobacterium tuberculosis.en
dc.description.affiliationSão Paulo State Univ UNESP, CEIS, Dept Biol, Inst Biosci Rio Claro, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationHC FMUSP, INCor, Discipline Allergy & Immunol, São Paulo, Brazil
dc.description.affiliationNatl Inst Sci & Technol Immunol INCT III, Alegre, RS, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, CEIS, Dept Biol, Inst Biosci Rio Claro, BR-13506900 Rio Claro, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipINCT-TB
dc.description.sponsorshipFinanciadora de Estudos e Projetos (FINEP)
dc.description.sponsorshipIdFAPESP: 06/57122-7
dc.format.extent1311-1317
dc.identifierhttp://dx.doi.org/10.2174/092986711795029528
dc.identifier.citationCurrent Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 18, n. 9, p. 1311-1317, 2011.
dc.identifier.doi10.2174/092986711795029528
dc.identifier.issn0929-8673
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/19711
dc.identifier.wosWOS:000288986300006
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Medicinal Chemistry
dc.relation.ispartofjcr3.469
dc.relation.ispartofsjr1,015
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectChorismate synthaseen
dc.subjectMycobacterium tuberculosisen
dc.subjectshikimate pathwayen
dc.titleUnderstanding the Structure, Activity and Inhibition of Chorismate Synthase from Mycobacterium tuberculosisen
dc.typeResenha
dcterms.licensehttp://www.benthamscience.com/permission.php
dcterms.rightsHolderBentham Science Publ Ltd
dspace.entity.typePublication
unesp.author.lattes2901888624506535
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.departmentBiologia - IBpt

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Rio Claro - IB - Instituto de Biociências