Publicação: Effect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetes
dc.contributor.author | Correa, Fernanda O. B. [UNESP] | |
dc.contributor.author | Goncalves, Daniela [UNESP] | |
dc.contributor.author | Figueredo, Carlos M. S. | |
dc.contributor.author | Bastos, Alliny S. [UNESP] | |
dc.contributor.author | Gustafsson, Anders | |
dc.contributor.author | Orrico, Silvana Regina Perez [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Karolinska Inst | |
dc.contributor.institution | Universidade do Estado do Rio de Janeiro (UERJ) | |
dc.date.accessioned | 2013-09-30T18:31:49Z | |
dc.date.accessioned | 2014-05-20T13:45:24Z | |
dc.date.available | 2013-09-30T18:31:49Z | |
dc.date.available | 2014-05-20T13:45:24Z | |
dc.date.issued | 2010-01-01 | |
dc.description.abstract | P>ObjectiveThe aim of this study was to investigate the effect of periodontal therapy on the circulating concentration of high-sensitivity capsule-reactive protein (hs-CRP), fibrinogen (FIB), interleukin (IL)-4, IL-6, IL-8, IL-10 and tumour necrosis factor-alpha (TNF-alpha) and on the metabolic control in type 2 diabetes mellitus (T2DM) patients.Material and MethodsTwenty-three T2DM patients with chronic periodontitis were enrolled in this study. Periodontal clinical parameters, namely visible plaque index, gingival bleeding index, bleeding on probing, probing depth and clinical attachment levels, were evaluated. Blood samples for plasma were collected and assessed for the levels of hs-CRP, FIB, IL-4, IL-6, IL-8, IL-10 and TNF-alpha. The glycated haemoglobin (HbA(1c)) and fasting plasma glucose were also measured. All parameters were evaluated before and 3 months after non-surgical periodontal therapy.ResultsAll clinical parameters were significantly improved 3 months after the periodontal therapy. A univariate comparison showed a tendency towards a decrease of the measured biomarkers, most pronounced for TNF-alpha and FIB, after therapy. Periodontal treatment also reduced HbA(1c) and hs-CRP levels, albeit not significantly.ConclusionsThe clinically successful non-surgical periodontal therapy tended to reduce systemic inflammation and the concentration of some circulating cytokines. | en |
dc.description.affiliation | São Paulo State Univ, Dept Diag & Surg, Sch Dent, Araraquara, SP, Brazil | |
dc.description.affiliation | Karolinska Inst, Div Periodontol, Inst Odontol, Stockholm, Sweden | |
dc.description.affiliation | Universidade do Estado do Rio de Janeiro (UERJ), Dept Periodontol, Sch Dent, Rio de Janeiro, RJ, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ, Dept Diag & Surg, Sch Dent, Araraquara, SP, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | CAPES: 0948/06-3 | |
dc.description.sponsorshipId | FAPESP: 04/08142-0 | |
dc.format.extent | 53-58 | |
dc.identifier | http://dx.doi.org/10.1111/j.1600-051X.2009.01498.x | |
dc.identifier.citation | Journal of Clinical Periodontology. Malden: Wiley-blackwell Publishing, Inc, v. 37, n. 1, p. 53-58, 2010. | |
dc.identifier.doi | 10.1111/j.1600-051X.2009.01498.x | |
dc.identifier.issn | 0303-6979 | |
dc.identifier.lattes | 7383391319292040 | |
dc.identifier.uri | http://hdl.handle.net/11449/15967 | |
dc.identifier.wos | WOS:000272771700008 | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing, Inc | |
dc.relation.ispartof | Journal of Clinical Periodontology | |
dc.relation.ispartofjcr | 4.046 | |
dc.relation.ispartofsjr | 2,079 | |
dc.rights.accessRights | Acesso restrito | pt |
dc.source | Web of Science | |
dc.subject | diabetes mellitus | en |
dc.subject | fibrinogen | en |
dc.subject | glycaemic control | en |
dc.subject | periodontal disease | en |
dc.subject | therapy | en |
dc.subject | tumour necrosis factor-alpha | en |
dc.title | Effect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetes | en |
dc.type | Artigo | pt |
dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dcterms.rightsHolder | Wiley-blackwell Publishing, Inc | |
dspace.entity.type | Publication | |
relation.isOrgUnitOfPublication | ca4c0298-cd82-48ee-a9c8-c97704bac2b0 | |
relation.isOrgUnitOfPublication.latestForDiscovery | ca4c0298-cd82-48ee-a9c8-c97704bac2b0 | |
unesp.author.lattes | 7383391319292040 | |
unesp.author.orcid | 0000-0003-0222-9231[3] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara | pt |
unesp.department | Diagnóstico e Cirurgia - FOAR | pt |
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