Logo do repositório
 

Cardiorespiratory and neuroendocrine changes induced by methadone in conscious and in isoflurane anaesthetised dogs

dc.contributor.authorGarofalo, Natache A. [UNESP]
dc.contributor.authorTeixeira Neto, Francisco José [UNESP]
dc.contributor.authorPereira, Carolina D. N. [UNESP]
dc.contributor.authorPignaton, Wangles [UNESP]
dc.contributor.authorVicente, Flavia [UNESP]
dc.contributor.authorAlvaides, Renata K. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:32:36Z
dc.date.available2014-05-20T15:32:36Z
dc.date.issued2012-12-01
dc.description.abstractThe aim of this study was to compare the cardiorespiratory and neurohormonal effects of methadone in conscious and in isoflurane anaesthetised dogs. Six mature dogs (28.0 +/- 3.8 kg bodyweight) received intravenous (IV) methadone (1 mg/kg) three times, once when conscious and twice during isoflurane anaesthesia (with a wash-out period of 1 week). The vasopressin antagonist relcovaptan (0.1 mg/kg IV) was administered before the methadone either during the first or second (selected randomly) isoflurane anaesthesia to evaluate the contribution of vasopressin to methadone-associated vasoconstriction. Cardiorespiratory data, plasma catecholamines and serum vasopressin were recorded before (baseline) and for 90 min after methadone.Methadone induced dysphoria in all conscious dogs and significantly (P < 0.05) increased mean arterial pressure (MAP), catecholamines, and vasopressin concentrations. During anaesthesia, in addition to significantly greater decreases in heart rate (HR) and cardiac index (Cl) than during the conscious state, methadone induced apnoea and mechanical ventilation was necessary in all dogs. In anaesthetised animals, methadone administration significantly increased vasopressin concentrations and systemic vascular resistance index (SVRI), while MAP did not differ from baseline. Relcovaptan administration did not modify the increase in SVRI associated with methadone injection during anaesthesia. Increases in plasma catecholamines may account for the slight decreases in HR and Cl seen after methadone administration in conscious dogs. In contrast, isoflurane enhanced the intensity of the cardiorespiratory changes induced by methadone. Vasoconstrictive responses associated with methadone did not appear to be induced by vasopressin.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Anestesiol, Fac Med, BR-18618970 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Cirurgia & Anestesiol Vet, Fac Med Vet & Zootecnia, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Anestesiol, Fac Med, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Cirurgia & Anestesiol Vet, Fac Med Vet & Zootecnia, BR-18618970 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/57772-4
dc.description.sponsorshipIdFAPESP: 08/50302-5
dc.format.extent398-404
dc.identifierhttp://dx.doi.org/10.1016/j.tvjl.2012.03.019
dc.identifier.citationVeterinary Journal. Oxford: Elsevier B.V., v. 194, n. 3, p. 398-404, 2012.
dc.identifier.doi10.1016/j.tvjl.2012.03.019
dc.identifier.issn1090-0233
dc.identifier.urihttp://hdl.handle.net/11449/41458
dc.identifier.wosWOS:000313224300028
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofVeterinary Journal
dc.relation.ispartofjcr1.773
dc.relation.ispartofsjr0,979
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMethadoneen
dc.subjectIsofluraneen
dc.subjectCanine anaesthesiaen
dc.subjectCatecholaminesen
dc.subjectVasopressinen
dc.titleCardiorespiratory and neuroendocrine changes induced by methadone in conscious and in isoflurane anaesthetised dogsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0002-3002-8093[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentCirurgia e Anestesiologia Veterinária - FMVZpt

Arquivos

Licença do pacote

Agora exibindo 1 - 2 de 2
Carregando...
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Carregando...
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: