Publication: New Δ-tocotrienol derivatives from Colombian propolis
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Coadvisor
Graduate program
Undergraduate course
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Article
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Acesso aberto
Abstract
Two new δ-tocotrienol derivatives with oxidized terminal chain: 5,6-dioxo-garcinoic acid (trans-13′-carboxy-5,6-dioxo-δ-tocotrienol) (2) and 5-hydroxy-8b-oxo garcinoic acid (trans-13′-carboxy-5-hydroxy-8b-oxo-δ-tocotrienol) (3), together with one known derivative garcinoic acid (trans-13′-carboxy-δ-tocotrienol) (1) were isolated from a Colombian propolis. Garcinoic acid was found as a propolis constituent for the first time. The isolated compounds and crude ethanolic extract demonstrated high antimicrobial activity against Staphylococcus aureus and Candida albicans (MICs range: 10–39 μg/ml) as well as promising antioxidant potential in DPPH assay. Compound 3 displayed highest radical scavenging activity, even higher than that of dl-α-tocopherol, used as a positive control.
Description
Keywords
antimicrobial activity, DPPH scavenging activity, garcinoic acid, Propolis, δ-tocotrienol derivatives
Language
English
Citation
Natural Product Research.
