Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera
dc.contributor.author | Bach-Elias, M. | |
dc.contributor.author | Bahia, D. | |
dc.contributor.author | Teixeira, D. C. | |
dc.contributor.author | Cicarelli, RMB | |
dc.contributor.institution | Cid | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:24:27Z | |
dc.date.available | 2014-05-20T13:24:27Z | |
dc.date.issued | 1998-10-01 | |
dc.description.abstract | We investigated the possibility that Chagas' patients develop an autoimmune response to human UsnRNPs (small nuclear ribonucleoprotein) or Sm epitopes. Using purified human UsnRNPs, we detected anti-human UsnRNPs antibodies in sera from patients suffering from Chagas' disease. The antibodies it-ere also detected using peptide enzyme-linked immunosorbent assays containing the Sm-motif 1 domain. The latter technique showed that 61% (31/51) of the Chagas' patients' sera contained antibodies against Sm-motif I. The detection of anti-UsnRNPs autoantibodies in Chagas patients' sera strongly encourages further studies using animal models to determine how these autoantibodies appear. | en |
dc.description.affiliation | Cid, CSIC, E-08034 Barcelona, Spain | |
dc.description.affiliation | UNESP, Fac Ciências Farmaceut, Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, Fac Ciências Farmaceut, Araraquara, SP, Brazil | |
dc.format.extent | 796-799 | |
dc.identifier | http://dx.doi.org/10.1007/s004360050490 | |
dc.identifier.citation | Parasitology Research. New York: Springer Verlag, v. 84, n. 10, p. 796-799, 1998. | |
dc.identifier.doi | 10.1007/s004360050490 | |
dc.identifier.issn | 0044-3255 | |
dc.identifier.uri | http://hdl.handle.net/11449/7582 | |
dc.identifier.wos | WOS:000076197400006 | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartof | Parasitology Research | |
dc.rights.accessRights | Acesso restrito | pt |
dc.source | Web of Science | |
dc.title | Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera | en |
dc.type | Artigo | pt |
dcterms.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
dcterms.rightsHolder | Springer | |
dspace.entity.type | Publication | |
relation.isDepartmentOfPublication | 5004bcab-94af-4939-b980-091ae9d0a19e | |
relation.isDepartmentOfPublication.latestForDiscovery | 5004bcab-94af-4939-b980-091ae9d0a19e | |
relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Ciências Biológicas - FCF | pt |
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