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Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus Venom

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dc.contributor.authorSangiorgio, F. [UNESP]
dc.contributor.authorSakate, M. [UNESP]
dc.contributor.authorNogueira, R. M. B.
dc.contributor.authorTostes, R. A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Oeste Paulista (UNOESTE)
dc.contributor.institutionCESUMAR
dc.date.accessioned2014-05-20T15:32:36Z
dc.date.available2014-05-20T15:32:36Z
dc.date.issued2008-01-01
dc.description.abstractThe present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.en
dc.description.affiliationSão Paulo State Univ UNESP, Dept Small Anim Med Clin & Toxicol, Sch Vet Med & Anim Husbrandy, Botucatu, SP, Brazil
dc.description.affiliationUniv Oeste Paulista, Univ Western São Paulo, Dept Small Anim Clin, Presidente Prudente, SP, Brazil
dc.description.affiliationCESUMAR, Maringa Univ Ctr, Maringa, Parana, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Small Anim Med Clin & Toxicol, Sch Vet Med & Anim Husbrandy, Botucatu, SP, Brazil
dc.format.extent82-99
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000100007
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 1, p. 82-99, 2008.
dc.identifier.fileS1678-91992008000100007.pdf
dc.identifier.issn1678-9199
dc.identifier.scieloS1678-91992008000100007
dc.identifier.urihttp://hdl.handle.net/11449/41469
dc.identifier.wosWOS:000254511600007
dc.language.isoeng
dc.publisherUniversidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjecthistopathologyen
dc.subjectCrotalus durissus terrificusen
dc.subjectdogsen
dc.subjecttreatmenten
dc.subjectintoxicationen
dc.titleHistopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus Venomen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
dcterms.rightsHolderCevap-unesp
dspace.entity.typePublication

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