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Effects of crotamine in human prostate cancer cell line

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dc.contributor.authorAlberghini-dos-Santos, João Victor
dc.contributor.authorSanchez, Caroline Andolfato
dc.contributor.authorBordon, Karla de Castro Figueiredo
dc.contributor.authorPucca, Manuela Berto [UNESP]
dc.contributor.authorAntunes, Lusânia Maria Greggi
dc.contributor.authorArantes, Eliane Candiani
dc.contributor.authorOliveira, Isadora Sousa de
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFederal University of Roraima
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2025-04-29T18:36:58Z
dc.date.issued2024-05-28
dc.description.abstractOur study presents the anticancer potential of crotamine from Crotalus durissus terrificus in human prostate cancer cell line DU-145. Crotamine isolation was conducted through RP-FPLC, its molecular mass analyzed by MALDI-TOF was 4881.4 kDa, and N-terminal sequencing confirmed crotamine identity. Crotamine demonstrated no toxicity and did not inhibit migration in HUVEC cells. Although no cell death occurred in DU-145 cells, crotamine inhibited their migration. Thus, crotamine presented potential to be a prototype of anticancer drug.en
dc.description.affiliationDepartment of BioMolecular Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo, SP
dc.description.affiliationDepartment of Clinical Analysis Toxicology and Food Science School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo, SP
dc.description.affiliationHealth and Sciences Postgraduate Program Federal University of Roraima, RR
dc.description.affiliationDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University, Araraquara
dc.description.affiliationUnespDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University, Araraquara
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 121616/2022-3
dc.description.sponsorshipIdFAPESP: 2019/10173-6
dc.description.sponsorshipIdFAPESP: 2020/13176-3
dc.description.sponsorshipIdFAPESP: 2021/11936-3
dc.description.sponsorshipIdCNPq: 307184/2020-0
dc.description.sponsorshipIdCNPq: 309399/2021-1
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2024.107746
dc.identifier.citationToxicon, v. 243.
dc.identifier.doi10.1016/j.toxicon.2024.107746
dc.identifier.issn1879-3150
dc.identifier.issn0041-0101
dc.identifier.scopus2-s2.0-85192195706
dc.identifier.urihttps://hdl.handle.net/11449/298379
dc.language.isoeng
dc.relation.ispartofToxicon
dc.sourceScopus
dc.subjectAnticancer
dc.subjectCPP
dc.subjectCrotalus durissus terrificus
dc.subjectDU-145
dc.subjectSnake venoms
dc.titleEffects of crotamine in human prostate cancer cell lineen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.orcid0000-0002-2036-1191[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas