Leaves of eugenia brasiliensis used as a folk medicine contain cyclooxygenase enzyme and lipid peroxidation inhibitory compounds

Dametto, Alessandra C. [UNESP]; Boralle, Nivaldo [UNESP]; Zhang, Chuan-Rui; Silva, Dulce H. S. [UNESP]; Nair, Muraleedharan G.

Leaves of eugenia brasiliensis used as a folk medicine contain cyclooxygenase enzyme and lipid peroxidation inhibitory compounds

Data

2018-01-01

Autores

Dametto, Alessandra C.

Boralle, Nivaldo

Zhang, Chuan-Rui

Silva, Dulce H. S.

Nair, Muraleedharan G.

Tipo

Artigo

Direito de acesso

Acesso restrito

Resumo

Tea prepared from leaves of Eugenia brasiliensis has been used as a folk medicine in Brazil to alleviate inflammation and pain. In this study, tea and methanolic extract inhibited cyclooxygenase (COX-1 and -2) enzymes and lipid peroxidation (LPO). Therefore, bioassay-guided purification of methanolic extract was carried out and afforded a new lignan (aR,8S,8’R-7,8,7’,8’-tetrahydro-8,8’-dimethyl-3,3’-dimethoxy-4,4’-dihydroxy-dibenzocyclooctadiene) and three known C-methylated flavonoids (stropopinin; demethoxymatteucinol; myrigalone G). All isolates at 37.5 µg/mL inhibited COX enzymes, similar to aspirin and ibuprofen used as controls at 108 and 12 µg/mL, respectively. Most of the isolates also showed strong LPO inhibition at 5µg/mL.