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Cold Atmospheric Pressure Plasma Jet Reduces Trichophyton rubrum Adherence and Infection Capacity

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dc.contributor.authorBorges, Aline Chiodi [UNESP]
dc.contributor.authorNishime, Thalita Mayumi Castaldelli [UNESP]
dc.contributor.authorde Moura Rovetta, Sabrina
dc.contributor.authorLima, Gabriela de Morais Gouvêa
dc.contributor.authorKostov, Konstantin Georgiev [UNESP]
dc.contributor.authorThim, Gilmar Patrocínio
dc.contributor.authorde Menezes, Beatriz Rossi Canuto
dc.contributor.authorMachado, João Paulo Barros
dc.contributor.authorKoga-Ito, Cristiane Yumi
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLeibniz Institute for Plasma Science and Technology (INP)
dc.contributor.institutionTaubaté Institute of Higher Education (ITES)
dc.contributor.institutionInstituto Tecnológico de Aeronáutica (ITA)
dc.contributor.institutionNational Institute for Space Research
dc.date.accessioned2019-10-06T16:44:59Z
dc.date.available2019-10-06T16:44:59Z
dc.date.issued2019-01-01
dc.description.abstractThis study aimed to evaluate the effects of cold atmospheric pressure plasma (CAPP) jet on Trichophyton rubrum growth, germination and adherence to nail. The effects of plasma jet on T. rubrum conidia germination and on mycelial growth were evaluated by in vitro assays. An ex vivo nail infection model was used to evaluate the effects on conidia adherence and infection. Biochemical analyses of nail fragments exposed or not to CAPP were performed by attenuated total reflectance–Fourier transform infrared (ATR–FTIR) spectroscopy. Plasma jet exposure for 10 and 15 min completely inhibited mycelial growth after only one exposure. Fifteen minutes of exposure could reduce conidia germination in suspension. Fungal suspensions exposed to plasma jet for 10 and 15 min were not able to infect nail specimens. These results were corroborated by ATR–FTIR analyses of nail fragments. In conclusion, single exposure to CAPP for 15 min was able to inhibit fungal growth, adherence and infection capacity. The results suggest that cold atmospheric plasma jet can be a promising alternative for the treatment of onychomycoses caused by T. rubrum.en
dc.description.affiliationDepartment of Environmental Engineering and Oral Biopathology Graduate Program Institute of Science and Technology São Paulo State University (UNESP), Avenida Engenheiro Francisco José Longo, 777
dc.description.affiliationDepartment of Chemistry and Physics Guaratinguetá Faculty of Engineering São Paulo State University (UNESP), Av. Dr. Ariberto Pereira da Cunha, 333
dc.description.affiliationLeibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Street 2
dc.description.affiliationDepartament of Pharmacy Taubaté Institute of Higher Education (ITES), Avenida Dom Pedro I, 3575
dc.description.affiliationDivision of Fundamental Sciences Instituto Tecnológico de Aeronáutica (ITA), Praça Marechal Eduardo Gomes, 50
dc.description.affiliationAssociated Laboratory for Sensors and Materials National Institute for Space Research, Avenida dos Astronautas, 1758
dc.description.affiliationUnespDepartment of Environmental Engineering and Oral Biopathology Graduate Program Institute of Science and Technology São Paulo State University (UNESP), Avenida Engenheiro Francisco José Longo, 777
dc.description.affiliationUnespDepartment of Chemistry and Physics Guaratinguetá Faculty of Engineering São Paulo State University (UNESP), Av. Dr. Ariberto Pereira da Cunha, 333
dc.identifierhttp://dx.doi.org/10.1007/s11046-019-00375-2
dc.identifier.citationMycopathologia.
dc.identifier.doi10.1007/s11046-019-00375-2
dc.identifier.issn1573-0832
dc.identifier.issn0301-486X
dc.identifier.lattes6543563161403421
dc.identifier.orcid0000-0002-2416-2173
dc.identifier.scopus2-s2.0-85071419219
dc.identifier.urihttp://hdl.handle.net/11449/189573
dc.language.isoeng
dc.relation.ispartofMycopathologia
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntifungal agents
dc.subjectCold plasma
dc.subjectOnychomycosis
dc.subjectTrichophyton rubrum
dc.titleCold Atmospheric Pressure Plasma Jet Reduces Trichophyton rubrum Adherence and Infection Capacityen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes6543563161403421[9]
unesp.author.orcid0000-0002-6097-9914[1]
unesp.author.orcid0000-0002-2416-2173[9]
unesp.departmentFísica e Química - FEGpt

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Guaratinguetá - FEG - Faculdade de Engenharia e Ciências