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HMGB1 and inflammatory cytokines in experimental acute lung injury induced in rabbits

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dc.contributor.authorKurokawa, C. S. [UNESP]
dc.contributor.authorJúnior, J.P. Araújo [UNESP]
dc.contributor.authorPires, R. B. [UNESP]
dc.contributor.authorCarpi, M. F. [UNESP]
dc.contributor.authorMoraes, M. A. [UNESP]
dc.contributor.authorMedeiros, L. T.L. [UNESP]
dc.contributor.authorFioretto, J. R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T01:38:15Z
dc.date.available2020-12-12T01:38:15Z
dc.date.issued2020-07-01
dc.description.abstractThe aim of this work was to measure HMGB1, TNF-alpha, and IL-8 in bronchoalveolar lavage (BAL), serum and TLR2 and TLR4mRNA expression in lung tissue of rabbits with two grades of acute lung injury (ALI). The animals were randomly assigned to groups with severe (S) and mild/moderate (MM) ALI, induced with warm saline, and a control group. HMGB1, TNF-alpha, IL-8, TLR2mRNA and TLR4mRNA were measured after ALI induction. The results showed increased levels of IL-8, TNF-alpha, HMGB1 and TLR4mRNA in the ALI groups. HMGB1, IL-8 and TNF-alpha concentrations in BAL were higher in S compared MM. Increased TLR4mRNA was observed in S and MM versus control. The results suggest an early participation of HMGB1 in ALI together with IL-8 and TNF-alpha and association with severity. TLR4 has early expression and role in ALI pathophysiology but is not associated with severity.en
dc.description.affiliationUnesp Faculdade de Medicina
dc.description.affiliationUnesp Instituto de Biociências
dc.description.affiliationUnespUnesp Faculdade de Medicina
dc.description.affiliationUnespUnesp Instituto de Biociências
dc.format.extent1329-1338
dc.identifierhttp://dx.doi.org/10.1590/1678-4162-11499
dc.identifier.citationArquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 72, n. 4, p. 1329-1338, 2020.
dc.identifier.doi10.1590/1678-4162-11499
dc.identifier.fileS0102-09352020000401329.pdf
dc.identifier.issn1678-4162
dc.identifier.issn0102-0935
dc.identifier.lattes8510423269540465
dc.identifier.orcid0000-0003-1380-7527
dc.identifier.scieloS0102-09352020000401329
dc.identifier.scopus2-s2.0-85090759700
dc.identifier.urihttp://hdl.handle.net/11449/199383
dc.language.isoeng
dc.relation.ispartofArquivo Brasileiro de Medicina Veterinaria e Zootecnia
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectAcute lung lesion (ALI)
dc.subjectCytokines
dc.subjectHMGB-1
dc.subjectLung lesion
dc.subjectRabbit
dc.titleHMGB1 and inflammatory cytokines in experimental acute lung injury induced in rabbitsen
dc.typeArtigopt
dspace.entity.typePublication
unesp.author.lattes8510423269540465[1]
unesp.author.orcid0000-0003-1380-7527[1]
unesp.author.orcid0000-0002-9153-1485[2]
unesp.author.orcid0000-0002-3961-5534[3]
unesp.author.orcid0000-0003-0007-1506[5]
unesp.author.orcid0000-0003-4034-5962[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt

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Botucatu - FMB - Faculdade de Medicina