In vivo preservation of the hybrid layer by chlorhexidine
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SAGE Publications
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Acesso restrito
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Resumo
Host-derived proteases have been reported to degrade the collagen matrix of incompletely-resin-infiltrated dentin. This study tested the hypothesis that interfacial degradation of resin-dentin bonds may be prevented or delayed by the application of chlorhexidine (CHX), a matrix metalloproteinase inhibitor, to dentin after phosphoric acid-etching. Contralateral pairs of resin-bonded Class I restorations in non-carious third molars were kept under intra-oral function for 14 months. Preservation of resin-dentin bonds was assessed by microtensile bond strength tests and TEM examination. In vivo bond strength remained stable in the CHX-treated specimens, while bond strength decreased significantly in control teeth. Resin-infiltrated dentin in CHX-treated specimens exhibited normal structural integrity of the collagen network. Conversely, progressive disintegration of the fibrillar network was identified in control specimens. Auto-degradation of collagen matrices can occur in resin-infiltrated dentin, but may be prevented by the application of a synthetic protease inhibitor, such as chlorhexidine.
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Palavras-chave
Chlorhexidine , Degradation , Etch-and-rinse adhesive , Hybrid layer , In vivo , MMP , bisphenol A bis(2 hydroxypropyl) ether dimethacrylate , chlorhexidine , dentin bonding agent , fibrillar collagen , matrix metalloproteinase , phosphoric acid , proteinase inhibitor , resin , single bond , unclassified drug , chemistry , dental acid etching , dental bonding , dental surgery , dentin , drug antagonism , human , materials testing , mechanical stress , methodology , surface property , tensile strength , time , transmission electron microscopy , ultrastructure , Acid Etching, Dental , Bisphenol A-Glycidyl Methacrylate , Composite Resins , Dental Bonding , Dental Restoration, Permanent , Dentin , Dentin-Bonding Agents , Fibrillar Collagens , Humans , Materials Testing , Matrix Metalloproteinases , Microscopy, Electron, Transmission , Phosphoric Acids , Protease Inhibitors , Stress, Mechanical , Surface Properties , Tensile Strength , Time Factors
Idioma
Inglês
Citação
Journal of Dental Research, v. 86, n. 6, p. 529-533, 2007.
