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First report of vancomycin-resistant staphylococci isolated from healthy carriers in Brazil

dc.contributor.authorPalazzo, ICV
dc.contributor.authorAraujo, MLC
dc.contributor.authorDarini, ALC
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:24:23Z
dc.date.available2014-05-20T15:24:23Z
dc.date.issued2005-01-01
dc.description.abstractReduced susceptibility or resistance to vancomycin has been reported among clinical isolates of staphylococci in previous studies. In the present study we report on the isolation of four vancomycin-resistant staphylococcal strains from healthy carriers inside and outside the hospital environment. These carriers did not receive treatment with any antibiotic. All coagulase-negative staphylococcal strains showed variable levels of resistance to several antimicrobial agents, including oxacillin, and unstable resistance to vancomycin, with decreased vancomycin MICs (<4 mg/liter) after 10 days of passage in a nonselective medium. However, exposure of these revertants to vancomycin selected staphylococcal strains resistant to vancomycin at very high frequencies (10(-2) and 10(-3)). The vancomycin resistance in these staphylococcal strains was not mediated by the van gene. The cell wall of the staphylococcal strains studied became thickest after culture in medium containing vancomycin, and the differences in cell wall thickness were statistically significant (P < 0.001). Thus, the thickening of the cell wall in these staphylococcal strains may be an important contributor to vancomycin resistance.en
dc.description.affiliationUSP, Fac Ciências Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUNESP, Fac Ciências Agr & Vet Jaboticabal, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Ciências Agr & Vet Jaboticabal, São Paulo, Brazil
dc.format.extent179-185
dc.identifierhttp://dx.doi.org/10.1128/JCM.43.1.179-185.2005
dc.identifier.citationJournal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 43, n. 1, p. 179-185, 2005.
dc.identifier.doi10.1128/JCM.43.1.179-185.2005
dc.identifier.fileWOS000226380400025.pdf
dc.identifier.issn0095-1137
dc.identifier.urihttp://hdl.handle.net/11449/34999
dc.identifier.wosWOS:000226380400025
dc.language.isoeng
dc.publisherAmer Soc Microbiology
dc.relation.ispartofJournal of Clinical Microbiology
dc.relation.ispartofjcr4.054
dc.relation.ispartofsjr2,256
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.titleFirst report of vancomycin-resistant staphylococci isolated from healthy carriers in Brazilen
dc.typeArtigopt
dcterms.licensehttp://journals.asm.org/site/misc/ASM_Author_Statement.xhtml
dcterms.rightsHolderAmer Soc Microbiology
dspace.entity.typePublication
unesp.author.orcid0000-0001-5433-926X[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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