Physicochemical properties of sildenafil citrate (Viagra) and sildenafil base
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Undergraduate course
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Wiley-Blackwell
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Article
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Acesso restrito
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Abstract
Sildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X-ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a = 26.98 Angstrom; b = 11.95 Angstrom; c = 16.68 Angstrom; beta = 106.97degrees. [II]: a = 8.66 Angstrom; b = 34.27 Angstrom; c = 8.93 Angstrom; beta = 96.63'. Both compounds decompose at 189.4degreesC [I] and 251.9degreesC [II]. Densities and refractive indices are given. (C) 2003 Wiley-Liss, Inc.
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Keywords
Viagra, sildenafil citrate, sildenafil base, bioinorganic chemistry
Language
English
Citation
Journal of Pharmaceutical Sciences. Hoboken: John Wiley & Sons Inc., v. 92, n. 10, p. 2140-2143, 2003.
