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Physicochemical properties of sildenafil citrate (Viagra) and sildenafil base

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dc.contributor.authorMelnikov, P.
dc.contributor.authorCorbi, P. P.
dc.contributor.authorCuin, A.
dc.contributor.authorCavicchioli, M.
dc.contributor.authorGuimaraes, W. R.
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:59Z
dc.date.available2014-05-20T15:21:59Z
dc.date.issued2003-10-01
dc.description.abstractSildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X-ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a = 26.98 Angstrom; b = 11.95 Angstrom; c = 16.68 Angstrom; beta = 106.97degrees. [II]: a = 8.66 Angstrom; b = 34.27 Angstrom; c = 8.93 Angstrom; beta = 96.63'. Both compounds decompose at 189.4degreesC [I] and 251.9degreesC [II]. Densities and refractive indices are given. (C) 2003 Wiley-Liss, Inc.en
dc.description.affiliationUFMS, Dept Phys, CCET, BR-79070900 Campo Grande, MS, Brazil
dc.description.affiliationUNESP, Inst Chem, Dept Gen & Inorgan Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Chem, Dept Gen & Inorgan Chem, BR-14801970 Araraquara, SP, Brazil
dc.format.extent2140-2143
dc.identifierhttp://dx.doi.org/10.1002/jps.10469
dc.identifier.citationJournal of Pharmaceutical Sciences. Hoboken: John Wiley & Sons Inc., v. 92, n. 10, p. 2140-2143, 2003.
dc.identifier.doi10.1002/jps.10469
dc.identifier.issn0022-3549
dc.identifier.urihttp://hdl.handle.net/11449/33046
dc.identifier.wosWOS:000185692500021
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Pharmaceutical Sciences
dc.relation.ispartofjcr3.075
dc.relation.ispartofsjr0,984
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectViagrapt
dc.subjectsildenafil citratept
dc.subjectsildenafil basept
dc.subjectbioinorganic chemistrypt
dc.titlePhysicochemical properties of sildenafil citrate (Viagra) and sildenafil baseen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Inorgânica - IQARpt

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Araraquara - IQAR - Instituto de Química