Rearranged Sesquiterpenes and Branched Polyketides Produced by the Endophyte Camarops sp.
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Elsevier B.V.
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Acesso aberto
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Two rearranged sesquiterpenes, 3,5,9-trihydroxy presilphiperfolane (1) and 4-deoxy-10-oxodihydrobotrydial (2), and two branched polyketides, 4-((E)-pent-1-enyl)-3-((1'S,2'S)-1',2'-dihydroxybut-3-enyl)5H- furan-2-one (3) and (2E,4R)-2,4-dimethylnon-2-enoic acid (4), along with three known compounds (2E,4S)-2,4-dimethyloct-2-enoicacid (5), xylarenone C (6), xylarenone D (7), were isolated from solid substrate cultures of Camarops sp., an endophyte of Alibertia macrophylla (Rubiaceae). The structures were established by means of NMR and HRESIMS analyses. The absolute stereochemistry of 3 was determined through the application of the modified Mosher method. Compounds 6 and 7 exhibited cytotoxic activity against leukemia (HL-60), melanoma (MDA/MB-435), colon (HCT-8) and glioblastoma (SF-295) human tumor lines, while compounds 4-7 presented acetylcholinesterase inhibition. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
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Rearranged sesquiterpenes, Branched polyketides, Endophytic fungus, Camarops sp., Alibertia macrophylla
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Inglês
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Phytochemistry Letters. Amsterdam: Elsevier Science Bv, v. 17, p. 251-257, 2016.
