Publication: Rearranged Sesquiterpenes and Branched Polyketides Produced by the Endophyte Camarops sp.
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Coadvisor
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Undergraduate course
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Publisher
Elsevier B.V.
Type
Article
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Acesso aberto
Abstract
Two rearranged sesquiterpenes, 3,5,9-trihydroxy presilphiperfolane (1) and 4-deoxy-10-oxodihydrobotrydial (2), and two branched polyketides, 4-((E)-pent-1-enyl)-3-((1'S,2'S)-1',2'-dihydroxybut-3-enyl)5H- furan-2-one (3) and (2E,4R)-2,4-dimethylnon-2-enoic acid (4), along with three known compounds (2E,4S)-2,4-dimethyloct-2-enoicacid (5), xylarenone C (6), xylarenone D (7), were isolated from solid substrate cultures of Camarops sp., an endophyte of Alibertia macrophylla (Rubiaceae). The structures were established by means of NMR and HRESIMS analyses. The absolute stereochemistry of 3 was determined through the application of the modified Mosher method. Compounds 6 and 7 exhibited cytotoxic activity against leukemia (HL-60), melanoma (MDA/MB-435), colon (HCT-8) and glioblastoma (SF-295) human tumor lines, while compounds 4-7 presented acetylcholinesterase inhibition. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
Description
Keywords
Rearranged sesquiterpenes, Branched polyketides, Endophytic fungus, Camarops sp., Alibertia macrophylla
Language
English
Citation
Phytochemistry Letters. Amsterdam: Elsevier Science Bv, v. 17, p. 251-257, 2016.
