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Behavioural and neurochemical effects of phosphatidylserine in MPTP lesion of the substantia nigra of rats

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dc.contributor.authorPerry, J. C.
dc.contributor.authorDa Cunha, C.
dc.contributor.authorAnselmo-Franci, J.
dc.contributor.authorAndreatini, R.
dc.contributor.authorMiyoshi, E.
dc.contributor.authorTufik, S.
dc.contributor.authorVital, MABF
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-05-20T15:20:43Z
dc.date.available2014-05-20T15:20:43Z
dc.date.issued2004-01-26
dc.description.abstractThe present study investigated the effects of intranigral MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) infusion on rats treated with phosphatidylserine and evaluated in two memory tasks and on striatal dopamine levels. The results indicated that MPTP produced a significant decrease in the avoidance number in comparison to sham-operated and non-operated rats submitted to a two-way avoidance task. MPTP-lesioned rats exhibited an increase in the latencies to find the platform in cued version of the water maze in comparison to sham-operated and non-operated animals. The tested toxin reduced striatal dopamine levels in comparison to sham-operated and non-operated groups. A final surprising result was that phosphatidylserine was unable to reverse the cognitive deficits produced by MPTP or the reduction of striatal dopamine levels. In conclusion, the data suggest that MPTP is a good model to study the early impairment associated with Parkinson's disease and phosphatidylserine did not improve the memory impairment induced by MPTP. (C) 2003 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal do Paraná (UFPF), Dept Farmacol, Setor Ciências Biol, BR-81531990 Curitiba, Parana, Brazil
dc.description.affiliationState Univ São Paulo, Fac Odontol, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnespState Univ São Paulo, Fac Odontol, Dept Physiol, São Paulo, Brazil
dc.format.extent225-233
dc.identifierhttp://dx.doi.org/10.1016/j.ejphar.2003.11.029
dc.identifier.citationEuropean Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 484, n. 2-3, p. 225-233, 2004.
dc.identifier.doi10.1016/j.ejphar.2003.11.029
dc.identifier.issn0014-2999
dc.identifier.urihttp://hdl.handle.net/11449/31951
dc.identifier.wosWOS:000188610800013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.ispartofjcr3.040
dc.relation.ispartofsjr1,057
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectphosphatidylserinept
dc.subjectMPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)pt
dc.subjectmemorypt
dc.subject(Rat)pt
dc.subjectParkinson's diseasept
dc.subjectdopaminept
dc.titleBehavioural and neurochemical effects of phosphatidylserine in MPTP lesion of the substantia nigra of ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication

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