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Long-term effects of insulin therapy, islet transplantation, and pancreas transplantation in the prevention of glomerular changes in kidneys of alloxan-induced diabetic rats

dc.contributor.authorSpadella, César Tadeu [UNESP]
dc.contributor.authorLerco, Mauro Masson [UNESP]
dc.contributor.authorMachado, JLM
dc.contributor.authorMacedo, Célia Sperandeo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:37:51Z
dc.date.available2014-05-20T13:37:51Z
dc.date.issued2005-10-01
dc.description.abstractGroups of inbred alloxan-induced diabetic rats were treated with insulin (I), islets (IT), or pancreas transplantation (PT). Nondiabetic (N) and untreated diabetic (D) control groups were concurrently included. Each group was divided into five subgroups of 10 rats and killed after follow-up of 1, 3, 6, 9, and 12 months. Clinical and laboratory parameters were recorded, and kidney ultrastructural and morphometric analyses performed in each 12-month subgroup, namely glomerular basement membrane (GM) thickening, podocyte number, and number/extension of slit diaphragms (S). Rats from the I group showed poor metabolic control of diabetes compared with N group control rats. However, successfully transplanted rats (IT and PT) had complete restoration to normal levels for all metabolic parameters. GM thickening was significantly higher in diabetic compared with control rats. In contrast, the numbers of podocytes and slits as well as slit extensions were significantly decreased. Insulin therapy did not prevent any alterations upon comparison of diabetic vs control rats. Despite good metabolic control in IT rats, the degree of kidney lesion control never compared with that achieved in PT rats. In this group all glomerular changes were similar to the age-dependent lesions observed in control rats. We conclude that either IT or PT may be a good option for diabetes treatment, although pancreas transplantation seems to be the most effective treatment to control chronic complications.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Surg, Sch Med, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Sch Med, Dept Pediat, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Surg, Sch Med, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Sch Med, Dept Pediat, BR-18618970 Botucatu, SP, Brazil
dc.format.extent3468-3471
dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2005.09.051
dc.identifier.citationTransplantation Proceedings. New York: Elsevier B.V., v. 37, n. 8, p. 3468-3471, 2005.
dc.identifier.doi10.1016/j.transproceed.2005.09.051
dc.identifier.issn0041-1345
dc.identifier.lattes6223012281302736
dc.identifier.lattes1912587398095182
dc.identifier.lattes4728690596167767
dc.identifier.urihttp://hdl.handle.net/11449/13111
dc.identifier.wosWOS:000233449400073
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransplantation Proceedings
dc.relation.ispartofjcr0.806
dc.relation.ispartofsjr0,422
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleLong-term effects of insulin therapy, islet transplantation, and pancreas transplantation in the prevention of glomerular changes in kidneys of alloxan-induced diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.advisor.lattes4728690596167767
unesp.author.lattes6223012281302736
unesp.author.lattes1912587398095182
unesp.author.orcid0000-0001-5514-6611[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentPediatria - FMBpt

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