Galleria mellonella as an experimental model for studying periodontopathogens
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Abstract
In the present study, Galleria mellonella was evaluated as a potential infection model for periodontal bacteria, more specifically, Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. All the bacteria evaluated were pathogenic to G. mellonella, causing their death in a concentration-dependent manner, and a decrease in their hemocyte count. Moreover, it was possible to recover the bacteria from the larvae hemolymph and determine the colony-forming units per larvae. G. mellonella is an effective model that may help to better understand the host-microbe interactions in periodontics.
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Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Galleria mellonella, Periodontal diseases, Porphyromonas gingivalis
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English
Citation
Journal of Indian Society of Periodontology, v. 24, n. 6, p. 593-596, 2020.
