Publicação:
Myocardial dysfunction with increased ventricular compliance in volume overload hypertrophy

dc.contributor.authorDe Stefano, Laercio Martins
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:32:51Z
dc.date.available2014-05-20T13:32:51Z
dc.date.issued2006-12-01
dc.description.abstractThe aim this study was to evaluate systolic and diastolic function in volume overload induced myocardial hypertrophy in rats.Volume overload myocardial hypertrophy was induced in thirteen male Wistar rats by creating infrarenal arteriovenous fistula (AVF). The results were compared with a SHAM operated group (n = 11). Eight weeks after surgery, tail-cuff blood pressure was recorded, then rats were sacrificed for isolated heart studies using Langendorffs preparation.AVF rats presented increased left and right ventricular weights, compared to controls. The increased normalized ventricular volume (V0/LVW, 0.141 +/- 0.035 mL/g vs. 0.267 +/- 0.071 mL/g, P < 0.001) in the AVF group indicated chamber dilation. Myocardial hydroxyproline concentration remained unchanged. There was a significant decrease in +dP/dt (3318 +/- 352 mm Hg s(-1) vs. 2769 +/- 399 mm Hg s(-1); P=0,002), end-systolic pressure-volume relation (246 +/- 56 mm Hg mL(-1) vs. 114 +/- 63 mm Hg mL(-1);, P < 0,001), and -dP/dt (1746 +/- 240 min Hg s(-1) vs. 1361 +/- 217 mm Hg s(-1), P < 0.001) in the AVF group, which presented increased ventricular compliance (Delta V-25: SHAM=0.172 +/- 0.05 mL vs. AVF=0.321 +/- 0.072 mL, P < 0.001) with preserved myocardial passive stiffness (Strain(25): SHAM=13.5 +/- 3.0% vs. AVF=12.3 +/- 1.9%, P > 0.05).We conclude that volume-overload induced hypertrophy causes myocardial systolic and diastolic dysfunction with increased ventricular compliance. These haemodynamic features help to explain the long-term compensatory phase of chronic volume overload before transition to overt congestive heart failure. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Fac Med Botucatu, Dept Clin Med, Botucatu Sch Med, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Med Botucatu, Dept Clin Med, Botucatu Sch Med, BR-18618000 São Paulo, Brazil
dc.format.extent784-789
dc.identifierhttp://dx.doi.org/10.1016/j.ejheart.2006.02.005
dc.identifier.citationEuropean Journal of Heart Failure. Amsterdam: Elsevier B.V., v. 8, n. 8, p. 784-789, 2006.
dc.identifier.doi10.1016/j.ejheart.2006.02.005
dc.identifier.issn1388-9842
dc.identifier.lattes6309835137998766
dc.identifier.lattes6990977122340795
dc.identifier.urihttp://hdl.handle.net/11449/11223
dc.identifier.wosWOS:000243255500003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Heart Failure
dc.relation.ispartofjcr10.683
dc.relation.ispartofsjr5,784
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcardiac hypertrophypt
dc.subjectventricular dilationpt
dc.subjectvolume overloadpt
dc.subjectmyocardial contractilitypt
dc.titleMyocardial dysfunction with increased ventricular compliance in volume overload hypertrophyen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes6309835137998766
unesp.author.lattes6990977122340795
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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