Publicação:
Development and validation of infrared spectroscopy method for the determination of darunavir in tabets

dc.contributor.authorKogawa, Ana Carolina [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:42Z
dc.date.available2016-01-28T16:56:42Z
dc.date.issued2013
dc.description.abstractDarunavir is a protease inhibitor used in the treatment of HIV infection. It is a pillar of therapy cocktail for patients with this virus. This work proposed the development and validation of an infrared spectroscopy method for the determination of darunavir in tablets. The method was completely validated according to the International Conference on Harmonization guidelines, showing accuracy, precision, selectivity, robustness and linearity. It was linear over the concentration range of 1.5-3.5 mg with correlation coefficients greater than 0.9991 and limits of detection and quantification of 0.12 and 0.36 mg, respectively. The validated method is very useful to the routine quality control of darunavir, since it does not use polluting reagents, it is simple and has low-cost.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus, CEP 14801-902, Araraquara, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus, CEP 14801-902, Araraquara, SP, Brasil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Desenvolvimento da UNESP (FUNDUNESP)
dc.format.extent1-6
dc.identifierhttp://dx.doi.org/10.5923/j.pc.20130301.01
dc.identifier.citationPhysical Chemistry, v. 33, n. 1, p. 1-6, 2013.
dc.identifier.doi10.5923/j.pc.20130301.01
dc.identifier.issn2167-7042
dc.identifier.lattes6638857912920334
dc.identifier.lattes9881720291571774
dc.identifier.urihttp://hdl.handle.net/11449/133810
dc.language.isoeng
dc.publisherScientific and Academic Publishing
dc.relation.ispartofPhysical Chemistry
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectDarunaviren
dc.subjectInfrareden
dc.subjectMethod validationen
dc.titleDevelopment and validation of infrared spectroscopy method for the determination of darunavir in tabetsen
dc.typeArtigo
dcterms.rightsHolderScientific and Academic Publishing
dspace.entity.typePublication
unesp.author.lattes6638857912920334
unesp.author.lattes9881720291571774
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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