Publicação: Development and validation of infrared spectroscopy method for the determination of darunavir in tabets
dc.contributor.author | Kogawa, Ana Carolina [UNESP] | |
dc.contributor.author | Salgado, Hérida Regina Nunes [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2016-01-28T16:56:42Z | |
dc.date.available | 2016-01-28T16:56:42Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Darunavir is a protease inhibitor used in the treatment of HIV infection. It is a pillar of therapy cocktail for patients with this virus. This work proposed the development and validation of an infrared spectroscopy method for the determination of darunavir in tablets. The method was completely validated according to the International Conference on Harmonization guidelines, showing accuracy, precision, selectivity, robustness and linearity. It was linear over the concentration range of 1.5-3.5 mg with correlation coefficients greater than 0.9991 and limits of detection and quantification of 0.12 and 0.36 mg, respectively. The validated method is very useful to the routine quality control of darunavir, since it does not use polluting reagents, it is simple and has low-cost. | en |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus, CEP 14801-902, Araraquara, SP, Brasil | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus, CEP 14801-902, Araraquara, SP, Brasil | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorship | Fundação de Desenvolvimento da UNESP (FUNDUNESP) | |
dc.format.extent | 1-6 | |
dc.identifier | http://dx.doi.org/10.5923/j.pc.20130301.01 | |
dc.identifier.citation | Physical Chemistry, v. 33, n. 1, p. 1-6, 2013. | |
dc.identifier.doi | 10.5923/j.pc.20130301.01 | |
dc.identifier.issn | 2167-7042 | |
dc.identifier.lattes | 6638857912920334 | |
dc.identifier.lattes | 9881720291571774 | |
dc.identifier.uri | http://hdl.handle.net/11449/133810 | |
dc.language.iso | eng | |
dc.publisher | Scientific and Academic Publishing | |
dc.relation.ispartof | Physical Chemistry | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Currículo Lattes | |
dc.subject | Darunavir | en |
dc.subject | Infrared | en |
dc.subject | Method validation | en |
dc.title | Development and validation of infrared spectroscopy method for the determination of darunavir in tabets | en |
dc.type | Artigo | |
dcterms.rightsHolder | Scientific and Academic Publishing | |
dspace.entity.type | Publication | |
unesp.author.lattes | 6638857912920334 | |
unesp.author.lattes | 9881720291571774 | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Fármacos e Medicamentos - FCF | pt |