Publicação:
The interaction between vitamin K nutriture and warfarin administration in patients with bacterial overgrowth due to atrophic gastritis

dc.contributor.authorCamilo, Maria E.
dc.contributor.authorPaiva, Sergio A.R. [UNESP]
dc.contributor.authorO'Brien, Maureen E.
dc.contributor.authorBooth, Sarah L.
dc.contributor.authorDavidson, Kenneth W.
dc.contributor.authorSokoll, Lori J.
dc.contributor.authorSadowski, James A.
dc.contributor.authorRussell, Robert M.
dc.contributor.institutionTufts University
dc.contributor.institutionService de Medicina
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:40Z
dc.date.available2014-05-27T11:19:40Z
dc.date.issued1998-12-01
dc.description.abstractAtrophic gastritis patients have intestinal bacterial overgrowth which could produce menaquinones. The aim of this study was to evaluate the interaction between a diet low in phylloquinone and minidoses of warfarin in subjects with and without bacterial overgrowth. Subjects with atrophic gastritis (indicated by serum pepsinogen ratio) and healthy volunteers were studied while fed a restrictive phylloquinone diet and while receiving a minidose of warfarin. Coagulation times, serum osteocalcin, serum undercarboxylated osteocalcin, plasma phylloquinone, plasma K-epoxide, plasma undercarboxylated prothrombin (PIVKA)-II and urinary gamma-carboxyglutamic acid (Gla) were measured. At baseline, there were no differences between groups for any variable measured. Comparisons between baseline and post intervention in both groups, showed significant increases in circulating levels of K-epoxide, PIVKA II and undercarboxylated osteocalcin. However, no differences were observed when comparisons were made between groups. Our data do not support the hypothesis that bacterial synthesis of menaquinones in patients with bacterial overgrowth due to atrophic gastritis confers considerable resistance to the effect of warfarin.en
dc.description.affiliationJean Mayer, United States Department of Agriculture Human Nutrition Research Center on Aging Tufts University, Boston, MA 02111
dc.description.affiliationUniversily Hospital de Santa Maria Service de Medicina, Lisbon
dc.description.affiliationFaculdade de Medicina de Botucatu, São Paulo, 18618-000
dc.description.affiliationUnespFaculdade de Medicina de Botucatu, São Paulo, 18618-000
dc.format.extent73-78
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10993569
dc.identifier.citationJournal of Nutrition, Health and Aging, v. 2, n. 2, p. 73-78, 1998.
dc.identifier.issn1279-7707
dc.identifier.scopus2-s2.0-0032228024
dc.identifier.urihttp://hdl.handle.net/11449/65645
dc.language.isoeng
dc.relation.ispartofJournal of Nutrition, Health and Aging
dc.relation.ispartofjcr2.868
dc.relation.ispartofsjr1,249
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAtrophic gastritis
dc.subjectBacterial overgrowth
dc.subjectMinidose warfarin
dc.subjectPhylloquinone
dc.subjectVitamin K status
dc.subjectanticoagulant agent
dc.subjectphytomenadione
dc.subjectvitamin K group
dc.subjectwarfarin
dc.subjectaged
dc.subjectanaerobic bacterium
dc.subjectatrophic gastritis
dc.subjectbiosynthesis
dc.subjectchemically induced disorder
dc.subjectdiet
dc.subjectdrug antagonism
dc.subjectdrug effect
dc.subjectfemale
dc.subjectfood drug interaction
dc.subjectgrowth, development and aging
dc.subjecthuman
dc.subjectintestine
dc.subjectmale
dc.subjectmicrobiology
dc.subjectmiddle aged
dc.subjectpH
dc.subjectvitamin K deficiency
dc.subjectAged
dc.subjectAnticoagulants
dc.subjectBacteria, Anaerobic
dc.subjectDiet
dc.subjectFemale
dc.subjectFood-Drug Interactions
dc.subjectGastritis, Atrophic
dc.subjectHumans
dc.subjectHydrogen-Ion Concentration
dc.subjectIntestines
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectVitamin K
dc.subjectVitamin K 1
dc.subjectVitamin K Deficiency
dc.subjectWarfarin
dc.titleThe interaction between vitamin K nutriture and warfarin administration in patients with bacterial overgrowth due to atrophic gastritisen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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