Synthesis, characterization, and biological activity of a new palladium(II) complex with deoxyalliin
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Undergraduate course
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Canadian Science Publishing
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Article
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Abstract
Synthesis, characterization, and biological activity of a new water-soluble Pd(II)-deoxyalliin (S-allyl-L-cysteine) complex are described in this article. Elemental and thermal analysis for the complex are consistent with the formula [Pd(C6H10NO2S)2]. 13C NMR, 1H NMR, and IR spectroscopy show coordination of the ligand to Pd(II) through S and N atoms in a square planar geometry. Final residue of the thermal treatment was identified as a mixture of PdO and metallic Pd. Antiproliferative assays using aqueous solutions of the complex against HeLa and TM5 tumor cells showed a pronounced activity of the complex even at low concentrations. After incubation for 24 h, the complex induced cytotoxic effect over HeLa cells when used at concentrations higher than 0.40 mmol/L. At lower concentrations, the complex was nontoxic, indicating its action is probably due to cell cycle arrest, rather than cell death. In agreement with these results, the flow cytometric analysis indicated that after incubation for 24 h at low concentrations of the complex cells are arrested in G0/G1. © 2005 NRC Canada.
Description
Keywords
Cancer Deoxyalliin Palladium(II) S-allyl-L-cysteine Tumor cells Cells Complexation Cytology Heat treatment Infrared spectroscopy Nuclear magnetic resonance spectroscopy Synthesis (chemical) Thermoanalysis Toxicity Tumors Antiproliferative assays Biological activity Cytometric analysis Elemental analysis Palladium compounds alliin deoxyalliin ligand nitrogen palladium complex sulfur unclassified drug animal experiment animal model aqueous solution atom cancer cell culture carbon nuclear magnetic resonance cell cycle cell cycle G0 phase cell cycle G1 phase concentration response culture medium drug activity drug cytotoxicity drug solubility drug synthesis flow cytometry geometry HeLa cell human human cell infrared spectroscopy mouse nonhuman proton nuclear magnetic resonance thermal analysis tumor cell line
Language
English
Citation
Canadian Journal of Chemistry, v. 83, n. 2, p. 104-109, 2005.
