CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
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Coadvisor
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Undergraduate course
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Springer
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Article
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Abstract
The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis.
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Keywords
BETA-GLUCAN, CELL WALL, HYPERGAMMAGLOBULINEMIA, PARACOCCIDIOIDOMYCOSIS, PARACOCCIDIOIDES-BRASILIENSIS
Language
English
Citation
Mycopathologia. Dordrecht: Springer, v. 121, n. 1, p. 1-5, 1993.
