Publication:
Involvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein

dc.contributor.authorda Silva, Osmar Gomes
dc.contributor.authorRossignoli, Patrícia de Souza [UNESP]
dc.contributor.authorCarrillo-Sepúlveda, Maria Alícia
dc.contributor.authorBarreto-Chaves, Maria Luiza Morais
dc.contributor.authorChies, Agnaldo Bruno
dc.contributor.institutionUniversidade de Marília (UNIMAR)
dc.contributor.institutionFaculdade de Medicina de Marília
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-02-24T13:58:07Z
dc.date.available2015-02-24T13:58:07Z
dc.date.issued2011
dc.description.abstractAlthough angiotensin II-induced venoconstriction has been demonstrated in the rat vena cava and femoral vein, the angiotensin II receptor subtypes (AT1 or AT2) that mediate this phenomenon have not been precisely characterized. Therefore, the present study aimed to characterize the pharmacological receptors involved in the angiotensin II-induced constriction of rat venae cavae and femoral veins, as well as the opposing effects exerted by locally produced prostanoids and NO upon induction of these vasomotorresponses. The obtained results suggest that both AT1 and AT2 angiotensin II receptors are expressed in both veins. Angiotensin II concentration–response curves were shifted toward the right by losartan but not by PD 123319 in both the vena cava and femoral vein. Moreover, it was observed that both 10−5 Mindomethacin and 10−4 M L-NAME improve the angiotensin II responses in the vena cava and femoral vein. In conclusion, in the rat vena cava and femoral vein, angiotensin II stimulates AT1 but not AT2 to induce venoconstriction, which is blunted by vasodilator prostanoids and NO.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Filosofia e Ciências - Campus de Marília, Marília, Rua Hygino Muzzy Filho, 737, Mirante, CEP 17525000, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Department of Pharmacology, Biosciences Institute of Botucatu, Marília, Rua Hygino Muzzy Filho, 737, Mirante, CEP 17525000, SP, Brasil
dc.format.extent112-117
dc.identifierhttp://dx.doi.org/10.1016/j.peptides.2010.10.010
dc.identifier.citationPeptides, v. 32, n. 1, p. 112-117, 2011.
dc.identifier.doi10.1016/j.peptides.2010.10.010
dc.identifier.issn0196-9781
dc.identifier.lattes2622975453563085
dc.identifier.orcid0000-0001-6946-1145
dc.identifier.urihttp://hdl.handle.net/11449/115481
dc.language.isoeng
dc.relation.ispartofPeptides
dc.relation.ispartofjcr2.851
dc.relation.ispartofsjr1,001
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.titleInvolvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral veinen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes2622975453563085[2]
unesp.author.orcid0000-0001-6946-1145[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Filosofia e Ciências, Maríliapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt

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