Recent advances in SARS-CoV-2 Spike protein and RBD mutations comparison between new variants Alpha (B.1.1.7, United Kingdom), Beta (B.1.351, South Africa), Gamma (P.1, Brazil) and Delta (B.1.617.2, India)
dc.contributor.author | Sanches, Paulo R.S. [UNESP] | |
dc.contributor.author | Charlie-Silva, Ives | |
dc.contributor.author | Braz, Helyson L.B. | |
dc.contributor.author | Bittar, Cíntia [UNESP] | |
dc.contributor.author | Freitas Calmon, Marilia [UNESP] | |
dc.contributor.author | Rahal, Paula [UNESP] | |
dc.contributor.author | Cilli, Eduardo M. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Federal University of Ceará | |
dc.date.accessioned | 2022-05-01T09:30:34Z | |
dc.date.available | 2022-05-01T09:30:34Z | |
dc.date.issued | 2021-09-01 | |
dc.description.abstract | New variants of SARS-CoV-2 Alpha (B.1.1.7); Beta (B.1.351) Gamma (P.1) and Delta (B.1.617.2) quickly spread in the UK, South Africa, Brazil and India, respectively. To address whether mutations in SARS-CoV-2 RBD spike protein could affect virus infectivity, peptides containing RBD amino acids mutations have been constructed and interacted with human ACE2 by computational methods. Our results suggest that mutations in RBD amino acids K417, E484, L452, T478 and N501 are expressively increasing the affinity of this protein with human angiotensin-converting enzyme 2 (ACE2), consequently, variants Alpha (B.1.1.7), Beta (B1.351), Gamma (P.1) and Delta (B.1.617.2) could be more infective in human cells compared with SARS-CoV-2 isolated in Wuhan-2019 and the Gamma and Delta variants could be the most infective among them. | en |
dc.description.affiliation | Institute of Chemistry UNESP - São Paulo State University | |
dc.description.affiliation | Institute of Biomedical Sciences Department of Pharmacology University of São Paulo | |
dc.description.affiliation | Department of Morphology School of Medicine Federal University of Ceará | |
dc.description.affiliation | Institute of Bioscience Language and Exact Science UNESP - São Paulo State University São José Do Rio Preto | |
dc.description.affiliationUnesp | Institute of Chemistry UNESP - São Paulo State University | |
dc.description.affiliationUnesp | Institute of Bioscience Language and Exact Science UNESP - São Paulo State University São José Do Rio Preto | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | FAPESP: FAPESP 20/05761–3 | |
dc.description.sponsorshipId | FAPESP: FAPESP 20/12519–4 | |
dc.identifier | http://dx.doi.org/10.1016/j.jve.2021.100054 | |
dc.identifier.citation | Journal of Virus Eradication, v. 7, n. 3, 2021. | |
dc.identifier.doi | 10.1016/j.jve.2021.100054 | |
dc.identifier.issn | 2055-6659 | |
dc.identifier.issn | 2055-6640 | |
dc.identifier.scopus | 2-s2.0-85115260703 | |
dc.identifier.uri | http://hdl.handle.net/11449/233558 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Virus Eradication | |
dc.source | Scopus | |
dc.subject | Human ACE2 | |
dc.subject | New variants | |
dc.subject | Receptor binding domain | |
dc.subject | SARS-CoV-2 | |
dc.subject | Spike protein | |
dc.title | Recent advances in SARS-CoV-2 Spike protein and RBD mutations comparison between new variants Alpha (B.1.1.7, United Kingdom), Beta (B.1.351, South Africa), Gamma (P.1, Brazil) and Delta (B.1.617.2, India) | en |
dc.type | Artigo | pt |
dspace.entity.type | Publication | |
relation.isOrgUnitOfPublication | bc74a1ce-4c4c-4dad-8378-83962d76c4fd | |
relation.isOrgUnitOfPublication.latestForDiscovery | bc74a1ce-4c4c-4dad-8378-83962d76c4fd | |
unesp.author.orcid | 0000-0003-1996-8831[3] | |
unesp.author.orcid | 0000-0001-5203-0103[5] | |
unesp.author.orcid | 0000-0002-4767-0904[7] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto | pt |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Química, Araraquara | pt |
unesp.department | Biologia - IBILCE | pt |
unesp.department | Bioquímica e Tecnologia - IQ | pt |