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Effect of injection of L-NAME on drinking response

dc.contributor.authorSaad, W.A. [UNESP]
dc.contributor.authorCamargo, L.A.A. [UNESP]
dc.contributor.authorSaad, R.
dc.contributor.authorPereira, A.F.
dc.contributor.authorSimões, S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Taubaté
dc.date.accessioned2014-05-20T15:11:31Z
dc.date.available2014-05-20T15:11:31Z
dc.date.issued1999-11-01
dc.description.abstractThe drinking behavior responses to centrally administered NG-nitro-L-arginine methyl ester (L-NAME; 10, 20 or 40 µg/µl), an inhibitor of nitric oxide synthase, were studied in satiated rats, with cannulae stereotaxically implanted into the lateral ventricle (LV) and subfornical organ (SFO). Water intake increased in all animals after angiotensin II (ANG II) injection into the LV, with values of 14.2 ± 1.4 ml/h. After injection of L-NAME at doses of 10, 20 or 40 µg/µl into the SFO before injection of ANG II (12 ng/µl) into the LV, water intake decreased progressively and reached basal levels after treatment with 0.15 M NaCl and with the highest dose of L-NAME (i.e., 40 µg). The water intake obtained after 40 µg/µl L-NAME was 0.8 ± 0.01 ml/h. Also, the injection of L-NAME, 10, 20 or 40 µg/µl, into the LV progressively reduced the water intake induced by hypertonic saline, with values of 5.3 ± 0.8, 3.2 ± 0.8 and 0.7 ± 0.01 ml/h, respectively. These results indicate that nitric oxide is involved in the regulation of drinking behavior induced by centrally administered ANG II and cellular dehydration and that the nitric oxide of the SFO plays an important role in this regulation.en
dc.description.affiliationUniversidade Estadual Paulista
dc.description.affiliationUniversidade de Taubaté
dc.description.affiliationUnespUniversidade Estadual Paulista
dc.format.extent1413-1416
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1999001100012
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 11, p. 1413-1416, 1999.
dc.identifier.doi10.1590/S0100-879X1999001100012
dc.identifier.fileS0100-879X1999001100012.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1999001100012
dc.identifier.urihttp://hdl.handle.net/11449/28061
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectnitric oxideen
dc.subjectwater intakeen
dc.subjectSFOen
dc.subjectdehydrationen
dc.subjectCNSen
dc.titleEffect of injection of L-NAME on drinking responseen
dc.typeArtigo
dspace.entity.typePublication

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