The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
| dc.contributor.author | Santos, Juliana I. Dos [UNESP] | |
| dc.contributor.author | Fernandes, Carlos A. H. [UNESP] | |
| dc.contributor.author | Magro, Angelo J. [UNESP] | |
| dc.contributor.author | Fontes, Marcos R. M. [UNESP] | |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
| dc.date.accessioned | 2022-04-28T20:54:50Z | |
| dc.date.available | 2022-04-28T20:54:50Z | |
| dc.date.issued | 2009-08-01 | |
| dc.description.abstract | Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity. © 2009 Bentham Science Publishers Ltd. | en |
| dc.description.affiliation | Departamento de Física e Biofisica Instituto de Biociéncias UNESP, Botucatu, SP | |
| dc.description.affiliation | Departamento de Física e Biofísica Instituto de Biociências UNESP, Botucatu, SP | |
| dc.description.affiliationUnesp | Departamento de Física e Biofisica Instituto de Biociéncias UNESP, Botucatu, SP | |
| dc.description.affiliationUnesp | Departamento de Física e Biofísica Instituto de Biociências UNESP, Botucatu, SP | |
| dc.format.extent | 887-893 | |
| dc.identifier | http://dx.doi.org/10.2174/092986609788923310 | |
| dc.identifier.citation | Protein and Peptide Letters, v. 16, n. 8, p. 887-893, 2009. | |
| dc.identifier.doi | 10.2174/092986609788923310 | |
| dc.identifier.issn | 0929-8665 | |
| dc.identifier.scopus | 2-s2.0-68849085882 | |
| dc.identifier.uri | http://hdl.handle.net/11449/225585 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Protein and Peptide Letters | |
| dc.source | Scopus | |
| dc.subject | Myotoxicity | |
| dc.subject | Oligomeric conformation | |
| dc.subject | Phospholipase a2 homologues | |
| dc.subject | Quaternary structure | |
| dc.subject | Snake venom | |
| dc.subject | X-ray crystallography | |
| dc.title | The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity | en |
| dc.type | Artigo | pt |
| dspace.entity.type | Publication | |
| relation.isOrgUnitOfPublication | ab63624f-c491-4ac7-bd2c-767f17ac838d | |
| relation.isOrgUnitOfPublication.latestForDiscovery | ab63624f-c491-4ac7-bd2c-767f17ac838d | |
| unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatu | pt |
| unesp.department | Física e Biofísica - IBB | pt |