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The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity

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dc.contributor.authorSantos, Juliana I. Dos [UNESP]
dc.contributor.authorFernandes, Carlos A. H. [UNESP]
dc.contributor.authorMagro, Angelo J. [UNESP]
dc.contributor.authorFontes, Marcos R. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T20:54:50Z
dc.date.available2022-04-28T20:54:50Z
dc.date.issued2009-08-01
dc.description.abstractPhospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity. © 2009 Bentham Science Publishers Ltd.en
dc.description.affiliationDepartamento de Física e Biofisica Instituto de Biociéncias UNESP, Botucatu, SP
dc.description.affiliationDepartamento de Física e Biofísica Instituto de Biociências UNESP, Botucatu, SP
dc.description.affiliationUnespDepartamento de Física e Biofisica Instituto de Biociéncias UNESP, Botucatu, SP
dc.description.affiliationUnespDepartamento de Física e Biofísica Instituto de Biociências UNESP, Botucatu, SP
dc.format.extent887-893
dc.identifierhttp://dx.doi.org/10.2174/092986609788923310
dc.identifier.citationProtein and Peptide Letters, v. 16, n. 8, p. 887-893, 2009.
dc.identifier.dimensionspub.1069158343
dc.identifier.doi10.2174/092986609788923310
dc.identifier.issn0929-8665
dc.identifier.issn1875-5305
dc.identifier.issn09298665
dc.identifier.orcid0000-0001-6515-6872
dc.identifier.orcid0000-0002-4253-6992
dc.identifier.pmid19689414
dc.identifier.scopus2-s2.0-68849085882
dc.identifier.urihttp://hdl.handle.net/11449/225585
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.relation.ispartofProtein and Peptide Letters
dc.rights.accessRightsAcesso abertopt
dc.rights.sourceRightsoa_all
dc.rights.sourceRightsgreen
dc.sourceScopus
dc.sourceDimensions
dc.subjectMyotoxicity
dc.subjectOligomeric conformation
dc.subjectPhospholipase a2 homologues
dc.subjectQuaternary structure
dc.subjectSnake venom
dc.subjectX-ray crystallography
dc.titleThe intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivityen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationab63624f-c491-4ac7-bd2c-767f17ac838d
relation.isOrgUnitOfPublication.latestForDiscoveryab63624f-c491-4ac7-bd2c-767f17ac838d
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFísica e Biofísica - IBBpt

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