Publicação: Chemical Profile and Cytotoxic Activity of Leaf Extracts from Senna spp. from Northeast of Brazil
Carregando...
Data
2016-10-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
Methanolic, diethyl ether and n-hexane extracts of leaves of four species of Senna (S. gardneri, S. macranthera, S. splendida and S. trachypus) were analyzed by gas chromatography coupled to mass spectrometry (GC-MS). Using linear retention indices and mass spectral data, 34 compounds were identified, including fatty acids, flavonoids, terpenoids and steroids that were not reported previously for these species. Additionally, the cytotoxicity of the extracts against different tumor cell lines was determined. The cytotoxicity was then correlated with the chemical composition of the extracts by partial least squares-discriminant analysis (PLS-DA). The n-hexane extract of S. gardneri and the ethyl ether extract of S. splendida were the most active against human colon (59.75 and 31.37%, respectively) and human glioblastoma (52.85 and 48.28%, respectively) cell lines.
Descrição
Palavras-chave
Idioma
Inglês
Como citar
Journal of the Brazilian Chemical Society. Sociedade Brasileira de Química, v. 27, n. 10, p. 1872-1880, 2016.
